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IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
TLDR
The increased immunity found in mice lacking IL-35 production by B cells was associated with a higher activation of macrophages and inflammatory T cells, as well as an increased function of B cells as antigen-presenting cells (APCs). Expand
The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+ dendritic cells
TLDR
XCR1 constitutes the first conserved specific marker for cell subsets homologous to mouse CD8α+ DCs in higher vertebrates and promotes their ability to activate early CD8+ T cell defenses against an intracellular pathogenic bacteria. Expand
Mitochondrial Antiviral Signaling Protein Plays a Major Role in Induction of the Fish Innate Immune Response against RNA and DNA Viruses
TLDR
This report provides the first demonstration that teleost fish possess a functional RLR pathway in which MAVS may play a central role in the induction of the innate immune response, conferring on fish cells full protection against RNA virus infection. Expand
The Two Groups of Zebrafish Virus-Induced Interferons Signal via Distinct Receptors with Specific and Shared Chains1
TLDR
Two subgroups of fish virus-induced IFNs have been defined based on conserved cysteines, and it is found that this subdivision correlates with receptor usage and all zebrafish IFNφs do not bind to the same receptor. Expand
Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System12
TLDR
Based on the organization of the zIFN gene and the protein structure of the identified receptor components, the virus-induced fish IFNs appear as orthologs of mammalian IFN-λ, specifying type III IFN as the ancestral antiviral system of vertebrates. Expand
Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate
TLDR
It is shown that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Expand
CXCL8 Chemokines in Teleost Fish: Two Lineages with Distinct Expression Profiles during Early Phases of Inflammation
TLDR
While both carp CXCL8s appear to be functional homologs of mammalian CxCL8, their different induction requirements and kinetics evoke a gene-specific sub-functionalization. Expand
Teleost Fish Mount Complex Clonal IgM and IgT Responses in Spleen upon Systemic Viral Infection
TLDR
The general properties of antibody responses were already in place in common ancestors of fish and mammals, and were globally conserved during evolution with possible functional convergences. Expand
Survey of Transcript Expression in Rainbow Trout Leukocytes Reveals a Major Contribution of Interferon-Responsive Genes in the Early Response to a Rhabdovirus Infection
TLDR
A more comprehensive view of the rainbow trout response to a viral infection is obtained using the subtractive suppressive hybridization methodology in the viral hemorrhagic septicemia model of infection, indicating that the interferon pathway is the predominant component of the anti-VHSV response. Expand
The Astonishing Diversity of Ig Classes and B Cell Repertoires in Teleost Fish
TLDR
A description of the organization of fish Ig loci is provided, with a particular emphasis on their heterogeneity between species, and recent data on the structure of the expressed Ig repertoire in healthy and infected fish is presented. Expand
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