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Pharmacology of Adenosine Receptors: The State of the Art.
An overview of current knowledge on adenosine receptors, including their characteristic structural features, molecular interactions and cellular functions, as well as their essential roles in pain, cancer, and neurodegenerative, inflammatory, and autoimmune diseases are offered.
The A3 adenosine receptor: an enigmatic player in cell biology.
The A3 Adenosine Receptor: History and Perspectives
It will become apparent in the present review that purine scientists do seem to be getting closer to their goal: the incorporation of adenosine ligands into drugs with the ability to save lives and improve human health.
Adenosine receptors and cancer.
A glance at adenosine receptors: novel target for antitumor therapy.
Adenosine signaling contributes to ethanol-induced fatty liver in mice.
- Zhongsheng Peng, P. Borea, B. Cronstein
- Medicine, BiologyThe Journal of clinical investigation
- 2 March 2009
Results indicate that adenosine generated by ethanol metabolism plays an important role in ethanol-induced hepatic steatosis via both A1 and A2B receptors and suggest that targeting adenosines receptors may be effective in the prevention of alcohol-induced fatty liver.
A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release
Investigating the A2A and A3ARs and their involvement in RA progression measured by Disease Activity Score in 28 or 44 joints demonstrated that the inflammatory and clinical responses in RA are regulated by A1 and A1 adenosine receptors, and support the use of A 2A and/or A3 AR agonists as novel and effective pharmacological treatment in RA patients.
Pulsed Electromagnetic Fields Increased the Anti-Inflammatory Effect of A2A and A3 Adenosine Receptors in Human T/C-28a2 Chondrocytes and hFOB 1.19 Osteoblasts
It is demonstrated that PEMF exposure significantly increase the anti-inflammatory effect of A2A or A3ARs suggesting their potential therapeutic use in the therapy of inflammatory bone and joint disorders.
A2A adenosine receptor overexpression and functionality, as well as TNF‐α levels, correlate with motor symptoms in Parkinson's disease
- K. Varani, F. Vincenzi, P. Borea
- Biology, MedicineFASEB journal : official publication of the…
- 1 February 2010
This is the first report showing the presence of an A2AAR alteration in putamen in PD that mirrors a similar up‐regulation in human peripheral blood cells, and highlights the central role of A 2AARs in the pharmacological treatment of PD.