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Mitochondrial Bioenergetics During Ischemia and Reperfusion.
- A. Consolini, M. I. Ragone, P. Bonazzola, Germán A. Colareda
- BiologyAdvances in experimental medicine and biology
An integrated view of previous and new results is explored which give evidences to the mitochondrial role in cardiac stunning by ischemia o hypoxia, and the influence of thyroid alterations and cardioprotective strategies, such as cardioplegic solutions and the phytoestrogen genistein in both sex.
Cardioprotective effect of hyperthyroidism on the stunned rat heart during ischaemia–reperfusion: energetics and role of mitochondria
- M. I. Ragone, P. Bonazzola, Germán A. Colareda, A. Consolini
- Medicine, BiologyExperimental physiology
- 1 June 2015
The findings contribute to the understanding of mitochondrial bioenergetics in pathology and support thyroid therapy in the stunning induced by ischaemia.
The heart extrasystole: an energetic approach.
- F. Marengo, M. T. Márquez, P. Bonazzola, J. Ponce-Hornos
- BiologyThe American journal of physiology
The results suggest that 1) the source of Ca2+ for ES would be entirely extracellular, 2) theCa2+ entered during ES is accumulated in the sarcoplasmic reticulum, and 3) the Ca2- stored by the sarcoplastic Reticulum during ES induces an increased contribution of this organelle during PES compared with the normal contraction.
Tension-dependent and tension-independent energy components of heart contraction
- J. Ponce-Hornos, P. Bonazzola, F. Marengo, A. Consolini, M. T. Márquez
- BiologyPflügers Archiv
- 1 April 1995
The presence of an H2 component during the twin contraction, its magnitude and Ca dependence gives support to a relationship between H2 and Ca removal processes and an association with Ca-binding processes (mainly Troponin C).
The energetics of the quiescent heart muscle: high potassium cardioplegic solution and the influence of calcium and hypoxia on the rat heart.
- M. T. Márquez, A. Consolini, P. Bonazzola, J. Ponce-Hornos
- BiologyActa physiologica Scandinavica
- 1 June 1997
In arterially perfused rat heart, raising [K]e from 7 to 25 mM at a constant extracellular Ca concentration ([Ca]e) induced an increase in resting heat production suggesting that the increased Hr associated with the verapamil sensitive fraction of heat released is associated to a mitochondrial mechanism.
Influence of extracellular potassium on energetics of resting heart muscle.
The work shows that the initial, transitory increase in resting heat production induced by increasing [K]e is caffeine sensitive and may be at least partially attributable to a transitory enhanced activity of the sarcoplasmic reticulum.
Effects of caffeine on energy output of rabbit heart muscle
The contractile process appeared to be more efficient in the presence of an active SR, since it is energetically less costly to generate a given level of isometric tension.
Cardioprotection of stevioside on stunned rat hearts: A mechano-energetical study.
Antitussive, antispasmodic, bronchodilating and cardiac inotropic effects of the essential oil from Blepharocalyx salicifolius leaves.
Energetics of Ca2+ homeostasis during ischemia-reperfusion on neonatal rat hearts under high-[K+] cardioplegia.
- A. Consolini, P. Bonazzola
- Biology, MedicineCanadian journal of physiology and pharmacology
- 4 December 2008
The sarcolemmal NCX was essential for removing the diastolic Ca2+ during the periods of CPG and I/R and the role of the sarcoplasmic reticulum store was evaluated by pretreating hearts with 10 mmol/L caffeine, which reduced contractile recovery only under isometric conditions or after increasing [Ca]o in CPG under isotonic conditions.