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Cooperative deformation of mineral and collagen in bone at the nanoscale
In biomineralized tissues such as bone, the recurring structural motif at the supramolecular level is an anisotropic stiff inorganic component reinforcing the soft organic matrix. The high toughnessExpand
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SAXS and USAXS on the high brilliance beamline at the ESRF
This article provides an overview of recent developments in time-resolved small-angle X-ray scattering on the high brilliance beamline (ID02) at the ESRF. With the image intensified CCD detector andExpand
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How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 A resolution.
BACKGROUND The enzyme methylmalonyl-coenzyme A (CoA) mutase, an alphabeta heterodimer of 150 kDa, is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. TheExpand
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Nanoscale deformation mechanisms in bone.
Deformation mechanisms in bone matrix at the nanoscale control its exceptional mechanical properties, but the detailed nature of these processes is as yet unknown. In situ tensile testing withExpand
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The myosin motor in muscle generates a smaller and slower working stroke at higher load
Muscle contraction is driven by the motor protein myosin II, which binds transiently to an actin filament, generates a unitary filament displacement or ‘working stroke’, then detaches and repeats theExpand
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In situ multi-level analysis of viscoelastic deformation mechanisms in tendon collagen.
Tendon is a hydrated multi-level fibre composite, in which time-dependent behaviour is well established. Studies indicate significant stress relaxation, considered important for optimising tissueExpand
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Extensibility and symmetry of actin filaments in contracting muscles.
When isometrically contracting muscles are subjected to a quick release followed by a shortening ramp of appropriate speed (V(o)), tension decays from its value at the isometric plateau (P(o)) to <0.Expand
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Mechanism of force generation by myosin heads in skeletal muscle
Muscles generate force and shortening in a cyclical interaction between the myosin head domains projecting from the myosin filaments and the adjacent actin filaments. Although many features of theExpand
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Intrafibrillar plasticity through mineral/collagen sliding is the dominant mechanism for the extreme toughness of antler bone.
  • H. Gupta, S. Krauss, +6 authors P. Fratzl
  • Materials Science, Medicine
  • Journal of the mechanical behavior of biomedical…
  • 1 December 2013
The inelastic deformability of the mineralised matrix in bones is critical to their high toughness, but the nanoscale mechanisms are incompletely understood. Antler is a tough bone type, with aExpand
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A multipurpose instrument for time-resolved ultra-small-angle and coherent X-ray scattering
The technical features and performance of a new instrument for time-resolved ultra-small-angle and coherent X-ray scattering are presented. The instrument enables static and kinetic investigationsExpand
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