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Autoregulation of serotonin neurons: role in antidepressant drug action.
The existence of an endogenous vasoconstrictor in blood serum ([Stevens and Lee, 1984][1]; [Brodie, 1900][2]) and the presence in the gut of a substance that increases intestinal motility ([VialliExpand
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Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
To investigate the contribution of individual serotonin (5-hydroxytryptamine; 5-HT) receptors to mood control, we have used homologous recombination to generate mice lacking specific serotonergicExpand
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Differences between males and females in rates of serotonin synthesis in human brain.
Rates of serotonin synthesis were measured in the human brain using positron emission tomography. The sensitivity of the method is indicated by the fact that measurements are possible even after aExpand
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Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.
Alterations in serotonin (5-hydroxytriptamine, 5-HT), norepinephrine, and gamma-aminobutyric acid have been linked to the pathophysiology of anxiety and depression, and medications that modulateExpand
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Is there a role for 5-HT1A agonists in the treatment of depression?
The role of serotonin (5-hydroxytryptamine; 5-HT) in the treatment of depressive and anxiety disorders is underscored by the therapeutic action of selective 5-HT reuptake inhibitors acting to enhanceExpand
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Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists
At clinically relevant doses, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and MAO inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphé nuclei, therebyExpand
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The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
Previous reviews have well illustrated how antidepressant treatments can differentially alter several neurotransmitter systems in various brain areas. This review focuses on the effects of distinctExpand
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Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders
BackgroundAnxiety and related disorders are among the most common mental disorders, with lifetime prevalence reportedly as high as 31%. Unfortunately, anxiety disorders are under-diagnosed andExpand
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Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions.
Anatomical studies have established the existence of reciprocal relationships between the main population of monoamine, serotonin (5-HT), norepinephrine (NE) and dopamine (DA) neurons in the brain.Expand
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Modifications of the Serotonin System by Antidepressant Treatments: Implications for the Therapeutic Response in Major Depression
Results of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments increase 5-hydroxytryptamine (5-HT) neurotransmission. TricyclicExpand
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