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Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
  • S. Ramboz, R. Oosting, R. Hen
  • Biology, Psychology
    Proceedings of the National Academy of Sciences…
  • 24 November 1998
It is demonstrated that mice without 5-HT1A receptors display decreased exploratory activity and increased fear of aversive environments (open or elevated spaces) and suggested that reductions in 5- HT1A receptor density due to genetic defects or environmental stressors might result in heightened anxiety.
Differences between males and females in rates of serotonin synthesis in human brain.
The mean rate of synthesis in normal males was found to be 52% higher than in normal females; this marked difference may be a factor relevant to the lower incidence of major unipolar depression in males.
Autoregulation of serotonin neurons: role in antidepressant drug action.
The existence of an endogenous vasoconstrictor in blood serum and the presence in the gut of a substance that increases intestinal motility had been known to scientists since the beginning of the century.
Is there a role for 5-HT1A agonists in the treatment of depression?
Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders
These guidelines were developed by Canadian experts in anxiety and related disorders through a consensus process based on global impression of efficacy, effectiveness, and side effects, using a modified version of the periodic health examination guidelines.
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.
It is shown that both genetic disruption and acute pharmacological blockade of the NK1R in mice result in a marked reduction of anxiety and stress-related responses and suggest that this effect is at least in part mediated by changes in the 5-HT system.
Modifications of the Serotonin System by Antidepressant Treatments: Implications for the Therapeutic Response in Major Depression
Results of electrophysiological single-cell recording studies suggest that most, if not all, types of antidepressant treatments increase 5-hydroxytryptamine (5-HT) neurotransmission. Tricyclic
Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions.
It was observed that the selective loss of DA neurons achieved by the intra-ventral tegmental area (VTA) injection of 6-OHDA increased the firing activity of a subset of locus coeruleus (LC) NE neurons, demonstrating a net inhibitory role of the NE input on VTA DA neurons.