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The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders.
TLDR
The importance of the histamine system as a therapeutic target to control the sleep-wake cycle and cognitive disorders will be discussed. Expand
Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats
TLDR
These observations provide the first evidence of a regulatory role of histamine H3 receptors on cortical acetylcholine release in vivo and suggest a role for histamine in learning and memory and may have implications for the treatment of degenerative disorders associated with impaired cholinergic function. Expand
Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.
TLDR
Direct, unambiguous evidence is provided that in rat striatum 5-HT3 receptors modulate release of endogenous dopamine from superfused rat striatal slices. Expand
Local GABAergic modulation of acetylcholine release from the cortex of freely moving rats
TLDR
Results suggest that cortically released GABA exerts a tonic influence on cholinergic activity in freely moving rats. Expand
Histamine receptors in the CNS as targets for therapeutic intervention.
TLDR
Recent developments in the pharmacological manipulation of H3Rs and the implications for H3R-related therapies for neurological and psychiatric disorders are discussed. Expand
Acetylcholine, histamine, and cognition: two sides of the same coin.
TLDR
Abnormal interactions between malfunctioning cholinergic and other neurotransmitter systems may cause additive or even synergistic effects on cognition, a phenomenon that warrants the increasing interest in understanding the complex physiology of brain systems affecting cognitive processes. Expand
Therapeutic potential of histamine H3 receptor agonists and antagonists.
TLDR
The available H3 receptor agonists and antagonists and their effects in a variety of pharmacological models in vitro and in vivo are described and the possible therapeutic applications of the various compounds are discussed. Expand
Aversive memory reactivation engages in the amygdala only some neurotransmitters involved in consolidation.
TLDR
It is shown that retrieved contextual fear memory is vulnerable to amnesic treatments and that the amygdala is critically involved, and these results help searching for appropriate therapeutic targets. Expand
The Akt/GSK‐3β axis as a new signaling pathway of the histamine H3 receptor
TLDR
It is shown that, in transfected SK‐N‐MC cells, the H3R modulates the activity of the Akt/Glycogen synthase kinase 3β axis both in a constitutive and agonist‐dependent fashion. Expand
The Akt/GSK-3beta axis as a new signaling pathway of the histamine H(3) receptor.
TLDR
It is shown that, in transfected SK-N-MC cells, the H(3)R modulates the activity of the Akt/Glycogen synthase kinase 3beta (GSK-3beta) axis both in a constitutive and agonist-dependent fashion. Expand
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