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PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
How the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms is discussed. Expand
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
Insulin stimulates the transport of glucose into fat and muscle cells. Although the precise molecular mechanisms involved in this process remain uncertain, insulin initiates its actions by binding toExpand
Flotillin and Epidermal Surface Antigen Define a New Family of Caveolae-associated Integral Membrane Proteins*
Flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected. Expand
OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
The collective data in cells, mice, and humans suggest that OXPAT is a marker for PPAR activation and fatty acid oxidation, which likely contributes to adaptive responses to the fatty acid burden that accompanies fasting, insulin deficiency, and overnutrition, responses that are defective in obesity and type 2 diabetes. Expand
A proposed model of fat packaging by exchangeable lipid droplet proteins
Five related structural proteins serve roles in packaging fat into lipid droplets and the tissue‐specific complement of these proteins determines how tissues manage lipid stores. Expand
Differential sorting and fate of endocytosed GPI‐anchored proteins
It is found that GPI‐APs are transported down the endocytic pathway to reducing late endosomes in BHK cells, using biochemical, morphological and functional approaches and this transport correlates with the association to raft‐like membranes and thus that lipid rafts are present in late endOSomes (in addition to the Golgi and the plasma membrane). Expand
S3-12, Adipophilin, and TIP47 Package Lipid in Adipocytes*
It is suggested that the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess. Expand
Targeting adipose tissue in the treatment of obesity-associated diabetes
An overview of the role of adipose tissue in metabolic homeostasis is provided and emerging novel therapeutic strategies targeting adipOSE tissue are assessed, including adipokine-based strategies, promotion of white adiposa tissue beiging as well as reduction of inflammation and fibrosis. Expand
The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria
Data show that PLIN5, in contrast to PLIN2, not only localizes to LD but also to mitochondria, possibly facilitating fatty acid oxidation, and involvement of PLin5 in directing fatty acids from the LD to mitochondrial fatty acids oxidation. Expand
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Total myocellular D AGs were markedly higher in highly trained athletes, corresponding with higher insulin sensitivity, and suggest a more complex role for DAGs in insulin action. Expand