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Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.
Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications
Bone marrow stromal cells are progenitors of skeletal tissue components such as bone, cartilage, the hematopoiesis‐supporting stroma, and adipocytes and represent an important paradigm of post‐natal nonhematopoietic stem cells, and an easy source for potential therapeutic use.
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells
Data show that myogenic precursors, distinct from satellite cells, are associated with microvascular walls in the human skeletal muscle, may represent a correlate of embryonic 'mesoangioblasts' present after birth and may be a promising candidate for future cell-therapy protocols in patients.
MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover
The findings demonstrate the pivotal function of MT1-MMP in connective tissue metabolism, and illustrate that modeling of the soft connective tissues matrix by resident cells is essential for the development and maintenance of the hard tissues of the skeleton.
Mesenchymal stem cells: revisiting history, concepts, and assays.
The experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their stemness and function are revisited.
The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Significant ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs, which have a major impact on their envisioned therapeutic use.
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting.
- M. Riminucci, M. Collins, +9 authors P. Gehron Robey
- MedicineThe Journal of clinical investigation
- 1 September 2003
It is found that FGF-23 is produced by normal and FD osteoprogenitors and bone-forming cells in vivo and in vitro and may play an important role in the renal phosphate-wasting syndrome associated with FD/MAS.
Stem cells in tissue engineering
The identification and isolation of stem cells from a number of tissues provides appropriate targets for prospective gene therapies and has the potential to significantly alter the perspective of tissue engineering.
Circulating Skeletal Stem Cells
- S. Kuznetsov, M. Mankani, S. Gronthos, K. Satomura, P. Bianco, P. Robey
- Biology, MedicineThe Journal of cell biology
- 28 May 2001
This work reports the isolation of adherent, clonogenic, fibroblast-like cells with osteogenic and adipogenic potential from the blood of four mammalian species, providing the first definitive proof of the existence of circulating skeletal stem cells in mammals.
Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome.
- S. Akintoye, C. Chebli, +8 authors M. Collins
- MedicineThe Journal of clinical endocrinology and…
- 1 November 2002
It was found that vision and hearing deficits were more common in patients with GH excess than in those without, and patients with a history of precocious puberty and GH excess who had reached skeletal maturity achieved normal adult height despite aHistory of early epiphyseal fusion.