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Prevalence of Giardia antigen in stool samples from dogs and cats
SUMMARY A total number of 153 faecal samples (105 from dogs and 48 from cats) were examined for the presence of Giardia infection by a commercially available enzyme immunoassay (ProspecT® GiardiaExpand
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Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling
Melatonin is known to exert antitumour activity in several types of human cancers, but the underlying mechanisms as well as the efficacy of different doses of melatonin are not well defined. Here, weExpand
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Brain adaptation to hypoxia and hyperoxia in mice
Aims Hyperoxic breathing might lead to redox imbalance and signaling changes that affect cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative stress. Our aim is toExpand
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Chronic systemic hypoxia promotes LNCaP prostate cancer growth in vivo
Solid tumors contain underperfused regions where hypoxia‐inducible factor‐1α (HIF‐1α) over‐expression induces hypoxia adaptation and cell proliferation. We test the hypothesis that systemic hypoxiaExpand
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Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts.
BACKGROUND/AIMS The simultaneous supplementation of creatine and D-ribose has been shown to reduce apoptosis in vitro in non-irreversibly injured cultured ischemic cardiomyocytes throughExpand
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Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
Ischemia and chronic hypoxia (CH) trigger a variety of adverse effects arising from metabolic stress that injures cells. In response to reduced O2, hypoxia-inducible factor 1α (HIF-1α) activatesExpand
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Phosphodiesterase-5 Inhibition Abolishes Neuron Apoptosis Induced by Chronic Hypoxia Independently of Hypoxia-Inducible Factor-1α Signaling
Exposure to hypoxia triggers a variety of adverse effects in the brain that arise from metabolic stress and induce neuron apoptosis. Overexpression of the hypoxia-inducible factor-1α (HIF-1α) isExpand
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Supplementation of Creatine and Ribose Prevents Apoptosis in Ischemic Cardiomyocytes
Background/Aims. To alleviate ischemia-induced injury in the myocardium, a tissue that depends critically on energy-yielding processes, creatine may be used to enhance energy metabolism, whereasExpand
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Xanthine Oxido-reductase Activity in Ischemic Human and Rat Intestine
We measured time course and extent of xanthine dehydrogenase (XD) to xanthine oxidase (XO) conversion in ischemic human and rat intestine. To model normothermic no-flow ischemia, we incubated freshExpand
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In vivo hyperoxia induces hypoxia-inducible factor-1α overexpression in LNCaP tumors without affecting the tumor growth rate.
Hypoxia is a recognized cause for solid tumors malignancy and resistance, probably via hypoxia-induced overexpression of the hypoxia-inducible factor (HIF)-1α, major modulator of the cell response toExpand
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