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Kinetic analysis of mouse retinal dehydrogenase type-2 (RALDH2) for retinal substrates.
Since RALDH2 has low K(m) and high catalytic efficiency for all-Trans retinal, it may likely be involved in the production of all-trans RA in vivo.
A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.
The identification of an aldehyde dehydrogenase in the rat kidney that catalysed the oxidation of 9-cis- and all-trans-retinal to corresponding retinoic acids with high efficiency is reported, with 9-Cis-Retinol being 2-fold more active than all- Trans-Retinoic acid.
Enzymatic characterization of recombinant mouse retinal dehydrogenase type 1.
The kinetic characterization of mRALDH1 is extended, insight is provided into the possible role of this enzyme in the biogenesis of RAs, and useful information is given on the determination of amino acid residues that play crucial roles in the catalysis of all-trans and 9-cis retinal.
All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice.
RA treatment improved insulin sensitivity and decreased the retinol:RBP4 ratio, suggesting that RA is an effective antidiabetic agent that could be considered in the treatment of type 2 diabetes.
Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency
  • P. Bhat
  • Biology, Medicine
    FEBS letters
  • 17 April 1998
The results show the differential expression of RALDH in the stomach and small intestine during postnatal development, and that vitamin A status regulates the expression ofRALDH gene in these tissues.
A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.
This study suggests that the ALDH1A2 rs7169289(G) variant might be protective for such individuals as maternal vitamin A deficiency is widespread in developing countries and may compromise availability of retinol for fetal RA synthesis.
Oxytocin in cardiac ontogeny.
A maximal OT and OTR protein level is shown in the developing rat heart at day 21 of gestation and postnatal days 1-4, when cardiac myocytes are at a stage of intense hyperplasia, suggesting that OT can be involved in developmental formation of the coronary vessels.
Recombinant Class I Aldehyde Dehydrogenases Specific for All-trans- or 9-cis-Retinal*
Recombinant enzymes with specificity for all-trans- or 9-cis-retinal were obtained, which should provide useful tools to study the relative importance of local production of all- trans- versus9-c is-retinoic acid in development and tissue differentiation.
Role of vitamin A in determining nephron mass and possible relationship to hypertension.
Vitamin A (retinol) and its analogs (retinoids) are important regulators of cell proliferation, differentiation, immune function, and apoptosis. The kidneys are target organs for vitamin A action.
Separation and estimation of retinyl fatty acyl esters in tissues of normal rat by high-performance liquid chromatography.
A reversed-phase high-performance liquid chromatography system for the complete separation of naturally occurring retinyl fatty acyl esters (RFAE) is described and it was found that, in liver tissue, the specific radioactivity of several RFAE was greater than that of retinyl palmitate.