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Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways
TLDR
The authors evaluated the association between polymorphisms in genes involved in the androgen biosynthesis and metabolism pathway and the risk of prostate carcinoma. Expand
Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43.
There is genetic predisposition associated with >=10% of all cancer of the prostate (CaP). By means of a genomewide search on a selection of 47 French and German families, parametric andExpand
Functional expression of sv40 in normal human prostatic epithelial and fibroblastic cells - differentiation pattern of nontumorigenic cell-lines.
TLDR
None of the cell lines analysed showed any tumourigenicity in nude mice over a period of 12 months, similar to the high apoptotic rate observed ipl vivo for normal prostate, particularly after castration should lead to a better understanding of the biology of the different cell compartments involved in the progression of prostate towards neoplasia. Expand
Immortalization of human adult normal prostatic epithelial cells by liposomes containing large T-SV40 gene.
TLDR
For the first time to the authors' knowledge, the immortalization of normal adult prostatic epithelial cells in culture by transfection of a plasmid containing SV40 genome with a defective replication origin encapsulated into liposomes is reported. Expand
Characterization, in some human breast cancer cell lines, of gastrin‐releasing peptide‐like receptors which are absent in normal breast epithelial cells
TLDR
Exogenous gastrin‐releasing peptide had no effect on growth of the cell lines when a serum‐free medium was used, implicating that in breast cancer cell lines this receptor does not mediate growth but has a functional role. Expand
(CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French–German population
TLDR
These polymorphisms can not be used as predictive parameters for prostate cancer in the French or German population because they are very similar in all four groups and chi square statistics on contingency tables did not detect any significant differences. Expand
Vitamin D receptor polymorphisms as markers in prostate cancer
TLDR
The present findings with the VDR gene agree with those from North America, indicating a weak but general role of the V DR in PCA susceptibility, and some association studies differ between Europe and North America. Expand
Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription-polymerase chain reaction assays.
TLDR
The data indicate that increased expression of the AR gene might play a key role in endocrine treatment failure, but it cannot be considered as the sole actor of this unresolved dilemma, and abnormalities in ER alpha and/or ER beta expression may also modulate the growth response of prostate cancer to hormone withdrawal. Expand
Quantification of expression of netrins, slits and their receptors in human prostate tumors
TLDR
A reduction in DCC, NEO1, NTN1 and NTN4 expression was observed in prostate tumors, while many of the same prostate tumors over‐expressed either Slit genes or their receptors, Robo. Expand
Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex.
TLDR
A transient AR expression model is established in non-tumorigenic prostate cells of both epithelial and mesenchymal origin and the natural ligand, dihydrotestosterone, stabilises the receptor and the AR is rapidly degraded at a nuclear location when the transfected cells are treated with Casodex. Expand
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