• Publications
  • Influence
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
TLDR
A single-nucleotide polymorphism in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%. Expand
Mutation of the Stargardt Disease Gene (ABCR) in Age-Related Macular Degeneration
TLDR
Identification of ABCR alterations will permit presymptomatic testing of high-risk individuals and may lead to earlier diagnosis of AMD and to new strategies for prevention and therapy. Expand
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
TLDR
A genome-wide association study of advanced age-related macular degeneration cases and controls using the Affymetrix 6.0 platform implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD. Expand
A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture.
TLDR
This cell line retains many of the metabolic and morphologic characteristics of RPE cells in vivo although there are some differences, particularly the loss of some enzymatic activities and cytoskeletal polarization. Expand
CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD
TLDR
The results suggest that CFH is a major risk factor of soft drusen, and additional genetic factors and/or environmental factors may be required for progression to advanced AMD. Expand
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications
  • Z. Tong, Z. Yang, +33 authors K. Zhang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 13 May 2008
TLDR
It is demonstrated that the T allele of SNP rs1617640 in the promoter of the EPO gene is significantly associated with PDR and ESRD in three European-American cohorts. Expand
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration.
TLDR
Identification of ABCR alterations will permit presymptomatic testing of high-risk individuals and may lead to earlier diagnosis of AMD and to new strategies for prevention and therapy. Expand
Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye.
TLDR
This report lends further support for the critical role of lutein, zeaxanthin, and other ocular carotenoids in protecting the eye from light-induced oxidative damage and aging. Expand
Identification of lutein and zeaxanthin oxidation products in human and monkey retinas.
TLDR
The proposed oxidative-reductive pathways for lutein and zeaxanthin in human retina, may therefore play an important role in prevention of age-related macular degeneration and cataracts. Expand
Chemistry, Distribution, and Metabolism of Tomato Carotenoids and Their Impact on Human Health
TLDR
The complete spectrum of carotenoids was identified and quantified from pooled human retinal pigment epithelium, ciliary body, iris, lens, and in the uveal tract and in other tissues of the human eye to gain a better insight into the metabolic pathways of ocular carotanoids. Expand
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