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A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affectsExpand
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Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results of a genome-wide association study of 979 advanced AMD cases and 1,709 controls usingExpand
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Mutation of the Stargardt Disease Gene (ABCR) in Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of severe central visual impairment among the elderly and is associated both with environmental factors such as smoking and with geneticExpand
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A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture.
PURPOSE A spontaneously arising, apparently transformed, cell line has been cloned from a primary culture of human retinal pigment epithelial (RPE) cells and has been subcultured more than 200 times.Expand
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CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMD
Background Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy and neovascularExpand
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Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration.
Age-related macular degeneration (AMD) is the leading cause of severe central visual impairment among the elderly and is associated both with environmental factors such as smoking and with geneticExpand
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Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications
  • Z. Tong, Z. Yang, +33 authors K. Zhang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 13 May 2008
Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications. Proliferative diabetic retinopathy (PDR)Expand
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Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye.
There is increasing evidence that the macular pigment carotenoids, lutein and zeaxanthin, may play an important role in the prevention of age-related macular degeneration, cataract, and otherExpand
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Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.
IMPORTANCE Oral supplementation with the Age-Related Eye Disease Study (AREDS) formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression toExpand
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Identification of lutein and zeaxanthin oxidation products in human and monkey retinas.
PURPOSE To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODSExpand
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