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Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.
It is demonstrated that neoadjuvant local low-dose gamma irradiation (LDI) causes normalization of aberrant vasculature and efficient recruitment of tumor-specific T cells in human pancreatic carcinomas and T-cell-mediated tumor rejection and prolonged survival in otherwise immune refractory spontaneous and xenotransplant mouse tumor models.
Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells
- R. Carretero, I. M. Sektioglu, N. Garbi, Oscar C. Salgado, P. Beckhove, G. Hämmerling
- Biology, MedicineNature Immunology
- 1 June 2015
It is reported that activated eosinophils were essential for tumor rejection in the presence of tumor-specific CD8+ T cells and secreted chemoattractants that guided T cells into the tumor, which resulted in tumor eradication and survival.
Bone marrow as a priming site for T-cell responses to blood-borne antigen
- M. Feuerer, P. Beckhove, +8 authors V. Schirrmacher
- Biology, MedicineNature Medicine
- 1 September 2003
It is demonstrated that naive, antigen-specific T cells home to bone marrow, where they can be primed, and highlighted the uniqueness of bone marrow as an organ important for hemato- and lymphopoiesis and for systemic T cell–mediated immunity.
Differentiation Therapy Exerts Antitumor Effects on Stem-like Glioma Cells
- B. Campos, Feng Wan, +17 authors C. Herold-Mende
- Biology, MedicineClinical Cancer Research
- 4 May 2010
It is shown that all-trans retinoic acid treatment alone can induce antitumor effects in vivo, and the potential of differentiation treatment to target the stem-like cell population in glioblastoma is highlighted.
Pancreatic cancer microenvironment
- J. Kleeff, P. Beckhove, +4 authors H. Friess
- Biology, MedicineInternational journal of cancer
- 15 August 2007
Evidence is accumulating that the cancer microenvironment plays an active role in disease progression, and efforts are being made to target this interplay between cancer cells and host cells to improve the outcome of this deadly disease.
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.
- A. Bonertz, J. Weitz, +12 authors P. Beckhove
- Biology, MedicineThe Journal of clinical investigation
- 2 November 2009
Differences in the repertoires of antigens recognized by Tregs and effector/memory T cells in the majority of colorectal cancer patients are detected, suggesting that the selection of antIGens according to preexisting T cell responses may improve the efficacy of future immunotherapies for cancer and autoimmune disease.
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.
It is reported that the ability of Treg cells to produce IL-10 and control inflammation is lost in the course of progressive disease in a mouse model of hereditary colon cancer.
Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.
Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human CRC and extends the impact of the local immune response on the clinical course from the primary tumor also to metastatic lesions.
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry
- S. Santegoets, E. Dijkgraaf, +15 authors S. H. van der Burg
- MedicineCancer Immunology, Immunotherapy
- 28 June 2015
An essential marker set comprising antibodies to CD3, CD4, CD25, CD127, Foxp3, Ki67, and CD45RA and a corresponding robust gating strategy for the context-dependent analysis of Tregs by flow cytometry is proposed.