• Publications
  • Influence
Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
Gender differences in outcome following cerebral ischemia have frequently been observed and attributed to the actions of steroid hormones. Progesterone has been shown to possess neuroprotectiveExpand
  • 150
  • 16
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy
Publication bias confounds attempts to use systematic reviews to assess the efficacy of various interventions tested in experiments modelling acute ischaemic stroke, leading to a 30% overstatement ofExpand
  • 438
  • 15
  • PDF
Association between hormone replacement therapy and subsequent stroke: a meta-analysis
Abstract Objectives To review completed trials assessing effect of hormone replacement therapy on subsequent risk of stroke, assessing stroke by pathological type, severity, and outcome. Table 1Expand
  • 202
  • 7
  • PDF
Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review.
Nitric oxide produced by the neuronal or inducible isoform of nitric oxide synthase (nNOS, iNOS) is detrimental in acute ischemic stroke (IS), whereas that derived from the endothelial isoform isExpand
  • 112
  • 7
The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial
BACKGROUND Raised blood pressure is common in acute stroke, and is associated with an increased risk of poor outcomes. We aimed to examine whether careful blood-pressure lowering treatment with theExpand
  • 315
  • 6
  • PDF
Serum S-100 Protein, Relationship to Clinical Outcome in Acute Stroke
The clinical significance of serum S-100 protein, a protein released by damaged brain tissue, was assessed in patients with acute ischaemic or haemorrhagic stroke and matched controls. Serum S-100Expand
  • 154
  • 6
Interventions for dysphagia in acute stroke.
BACKGROUND It is unclear how dysphagic patients should be fed and treated after acute stroke. OBJECTIVES The objective of this review was to assess the effect of different management strategies forExpand
  • 185
  • 6
  • PDF
G-CSF Reduces Infarct Volume and Improves Functional Outcome after Transient Focal Cerebral Ischemia in Mice
Growth factors possess neuroprotective and neurotrophic properties in vitro, but few have been extensively studied in vivo after stroke. In the present study, we investigated the potential functionalExpand
  • 152
  • 6
  • PDF
Quadriceps muscle weakness following acute hemiplegic stroke
Objective: To determine whether quadriceps muscle weakness develops on the side ipsilateral to the brain lesion in the first week following acute ischaemic hemiplegic stroke. Design: A prospectiveExpand
  • 103
  • 5
Progesterone for the treatment of experimental brain injury; a systematic review.
Steroid sex hormones are potential neuroprotective candidates following CNS injury. All clinical trials to date have examined the effects of oestrogen alone or oestrogen-progestin combinationExpand
  • 169
  • 4
  • PDF