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A Molecular Phylogeny for Bats Illuminates Biogeography and the Fossil Record
Bats make up more than 20% of extant mammals, yet their evolutionary history is largely unknown because of a limited fossil record and conflicting or incomplete phylogenies. Here, we present a highlyExpand
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Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
  • P. Bates
  • Biology, Medicine
  • International journal for parasitology
  • 1 August 2007
A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms thatExpand
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Enhancement of protein modeling by human intervention in applying the automatic programs 3D‐JIGSAW and 3D‐PSSM
TLDR
Fourteen models were constructed and analyzed for the comparative modeling section of Critical Assessment of Techniques for Protein Structure Prediction (CASP4). Expand
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Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Leishmania parasites cause a spectrum of clinical pathology in humans ranging from disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference genome for LeishmaniaExpand
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Reversal of DNA alkylation damage by two human dioxygenases
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1-methyladenine and 3-methylcytosine, which are generated in single-strandedExpand
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Global topological features of cancer proteins in the human interactome
TLDR
We report a study of cancer proteins in an extensive human protein-protein interaction network constructed by computational methods. Expand
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Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
TGF-β-induced Smad signal transduction from the membrane into the nucleus is not linear and unidirectional, but rather a dynamic network that couples Smad phosphorylation and dephosphorylationExpand
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The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis.
Transmission of leishmaniasis is effected by a specific developmental stage, the metacyclic promastigote. The precursors of metacyclic promastigotes were a distinct subpopulation of parasites,Expand
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Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG
Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models ofExpand
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Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
We present an updated and integrated version of our widely used protein-protein docking and binding affinity benchmarks. The benchmarks consist of non-redundant, high-quality structures ofExpand
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