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MR diffusion tensor spectroscopy and imaging.
Once Deff is estimated from a series of NMR pulsed-gradient, spin-echo experiments, a tissue's three orthotropic axes can be determined and the effective diffusivities along these orthotropic directions are the eigenvalues of Deff. Expand
Estimation of the effective self-diffusion tensor from the NMR spin echo.
Estimation of Deff provides the theoretical basis for a new MRI modality, diffusion tensor imaging, which provides information about tissue microstructure and its physiologic state not contained in scalar quantities such as T1, T2, proton density, or the scalar apparent diffusion constant. Expand
In vivo fiber tractography using DT‐MRI data
Fiber tract trajectories in coherently organized brain white matter pathways were computed from in vivo diffusion tensor magnetic resonance imaging (DT‐MRI) data, and the method holds promise for elucidating architectural features in other fibrous tissues and ordered media. Expand
Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.
Quantitative-diffusion-tensor MRI consists of deriving and displaying parameters that resemble histological or physiological stains, i.e., that characterize intrinsic features of tissueExpand
Toward a quantitative assessment of diffusion anisotropy
New indices calculated from the entire diffusion tensor are rotationally invariant (RI) and show that anisotropy is highly variable in different white matter regions depending on the degree of coherence of fiber tract directions. Expand
Diffusion tensor MR imaging of the human brain.
A quantitative characterization of water diffusion in anisotropic, heterogeneously oriented tissues is clinically feasible and should improve the neuroradiologic assessment of a variety of gray and white matter disorders. Expand
Inferring microstructural features and the physiological state of tissues from diffusion‐weighted images
  • P. Basser
  • Mathematics, Medicine
  • NMR in biomedicine
  • 1 November 1995
This work reviews several methods that have been developed to infer microstructural and physiological information about isotropic and anisotropic tissues from diffusion weighted images (DWIs) and furnishes scalar parameters that behave like quantitative histological or physiological‘stains’ for different features of diffusion. Expand
Axcaliber: A method for measuring axon diameter distribution from diffusion MRI
A new NMR‐based approach that employs a model of water diffusion within “restricted” cylindrical axons to estimate their diameter distribution within a nerve bundle is proposed and validated by comparing the diameter distributions measured using the NMR and histological techniques on sciatic and optic nerve tissue specimens. Expand
Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain
An experimental design and analysis framework to implement CHARMED MRI that is feasible on human clinical scanners is provided and it is assumed that these images might be more sensitive than DTI to white matter disorders. Expand
Diffusion MRI: From Quantitative Measurement to In vivo Neuroanatomy
Developments in the last century have led to a better understanding of diffusion, the perpetual mixing of molecules caused by thermal motion. In this chapter, the basic principles governing theExpand