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Brucella lipoproteins mimic dendritic cell maturation induced by Brucella abortus.
TLDR
It is demonstrated that B. abortus lipoproteins can stimulate DC maturation providing a mechanism by which these bacteria generate a Th1-type immune response. Expand
Brucella abortus inhibits IFN-γ-induced FcγRI expression and FcγRI-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages.
TLDR
It is reported here that infection with B. abortus down-modulates the expression of the type I receptor for the Fc portion of IgG and FcγRI-restricted phagocytosis regulated by IFN-γ in human monocytes/macrophages. Expand
Immunization with Recombinant Brucella Species Outer Membrane Protein Omp16 or Omp19 in Adjuvant Induces Specific CD4+ and CD8+ T Cells as Well as Systemic and Oral Protection against Brucella
TLDR
Flow cytometric analysis showed that immunization with U-Omp16 or U- omp19 induced antigen-specific CD4+ as well as CD8+ T cells producing gamma interferon, indicating that both cell types are mediating immune protection. Expand
Endogenous glucocorticoids modulate neutrophil function in a murine model of haemolytic uraemic syndrome
TLDR
It is concluded that Stx2 activates PMN and that the absence of endogenous GC enhances this activation suggesting that endogenous GC can, at least partially, counteract PMN inflammatory functions. Expand
Impaired neutrophils in children with the typical form of hemolytic uremic syndrome
TLDR
The results suggest that upon hospitalization D+HUS PMN are functionally impaired and show features of previous degranulation, indicating a preceding process of activation with release of ROS and proteases involved in endothelial damage. Expand
A Novel Function for Galectin-1 at the Crossroad of Innate and Adaptive Immunity: Galectin-1 Regulates Monocyte/Macrophage Physiology through a Nonapoptotic ERK-Dependent Pathway1
TLDR
Evidence is provided of a novel unrecognized role for galectin-1 in the control of monocyte/macrophage physiology with potential implications at the crossroad of innate and adaptive immunity. Expand
An Oral Vaccine Based on U-Omp19 Induces Protection against B. abortus Mucosal Challenge by Inducing an Adaptive IL-17 Immune Response in Mice
TLDR
The results indicate that an oral unadjuvanted vaccine based on U-Omp19 induces protection against a mucosal challenge with Brucella abortus by inducing an adaptive IL-17 immune response and indicate different and important new aspects i) IL- 17 does not contribute to reduce the bacterial burden in non vaccinated mice and ii) IL -17 plays a central role in vaccine mediated anti-Brucella mucosal immunity. Expand
Specific lytic activity against mycobacterial antigens is inversely correlated with the severity of tuberculosis
TLDR
It can be concluded that shifts in the CTL response and the cytolytic mechanisms take place as the pulmonary involvement becomes more severe. Expand
Proinflammatory response of human endothelial cells to Brucella infection.
Although vascular pathologies such as vasculitis, endocarditis and mycotic aneurysms have been described in brucellosis patients, the interaction of Brucella with the endothelium has not beenExpand
A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses.
We report here that a bacterial protease inhibitor from Brucella spp. called U-Omp19 behaves as an ideal constituent for a vaccine formulation against infectious diseases. When co-administered orallyExpand
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