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Improving public health information: a data quality intervention in KwaZulu-Natal, South Africa.
OBJECTIVE To evaluate the effect of an intervention to improve the quality of data used to monitor the prevention of mother-to-child transmission (PMTCT) of the human immunodeficiency virus in SouthExpand
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Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice.
The amiloride-sensitive epithelial sodium channel, ENaC, is a heteromultimeric protein made up of three homologous subunits (alpha, beta and gamma) (1,2). In vitro, assembly and expression ofExpand
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Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome.
OBJECTIVE AND STUDY DESIGN Successful adaptation to air breathing at birth depends on rapid absorption of fetal lung liquid that is mediated by activation of amiloride-sensitive sodium ion channels.Expand
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Improving a Mother to Child HIV Transmission Programme through Health System Redesign: Quality Improvement, Protocol Adjustment and Resource Addition
Background Health systems that deliver prevention of mother to child transmission (PMTCT) services in low and middle income countries continue to underperform, resulting in thousands of unnecessaryExpand
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A framework for scaling up health interventions: lessons from large-scale improvement initiatives in Africa
BackgroundScaling up complex health interventions to large populations is not a straightforward task. Without intentional, guided efforts to scale up, it can take many years for a new evidence-basedExpand
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Sweat-testing in preterm and full-term infants less than 6 weeks of age.
Our objective was to examine the characteristics of preterm and full-term infants < or = 6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and correspondingExpand
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Antiretroviral Drugs in the Cupboard are Not Enough: The Impact of Health Systems' Performance on Mother-to-Child Transmission of HIV
Objective:To model the effect of health systems performance on rates of mother-to-child HIV transmission. Methods:We modeled the effect of variation in performance of the multiple steps of differentExpand
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Pulmonary glucose transport in the fetal sheep.
1. In the chronically catheterized sheep fetus between 122 and 143 days gestation the concentration of D-glucose in lung liquid was very low (usually less than 0.01 mM, the lower limit of detectionExpand
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A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism.
Aldosterone-dependent epithelial sodium transport in the distal nephron is mediated by the absorption of sodium through the highly selective, amiloride-sensitive epithelial sodium channel (ENaC) madeExpand
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Macrolide antibiotics for cystic fibrosis.
BACKGROUND Cystic Fibrosis is characterised by chest infection, the antibiotic treatment of which has significantly improved the outlook for people with this condition. The unusual nature ofExpand
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