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Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.
We tested a new synthetic, 8-hydroxyquinoline-based, hexadentate iron chelator, O-Trensox and compared it with desferrioxamine B (DFO). Iron mobilisation was evaluated: (i) in vitro by using ferritinExpand
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Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent.
A synthetic siderophore, O-Trensox (L), has been designed and synthesized to improve iron nutrition of plants. The affinity for iron of this ligand [pFe(III) = 29.5 and pFe(II) = 17.9] is very highExpand
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Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines.
We investigated the effects of a new iron chelator, O-Trensox (TRX), compared with desferrioxamine (DFO), on proliferation and apoptosis in cultures of the human hepatoblastoma HepG2 andExpand
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Hydroxyquinolines as iron chelators.
The interest in synthetic siderophore mimics includes therapeutic applications (iron chelation therapy), the design of more effective agents to deliver Fe to plants and the development of newExpand
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O-TRENSOX, a New Tripodal Iron Chelator Based on 8-Hydroxyquinoline Subunits: Thermodynamic and Kinetic Studies
The thermodynamic stability of Fe(III) complexes with a new hexadentate tripodal ligand (O-TRENSOX) incorporating three 8-hydroxyquinoline (“oxine”) subunits, linked to a tetraamine (“TREN”) via an...
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Discovery of powerful uranyl ligands from efficient synthesis and screening.
New tripodal gem-(bis-phosphonates) uranophiles were discovered by a screening method that allowed for the selection of ligands with strong uranyl-binding properties in a convenient microtiter-plateExpand
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Synthesis and iron(III) complexing ability of CacCAM, a new analog of enterobactin possessing a free carboxylic anchor arm. Comparative studies with TRENCAM
A new tricatecholate, CacCAM, has been synthesized by attachment of three catecholamide subunits to a CO2H-functionalized triamine backbone. The solution coordination chemistry of the ligand and itsExpand
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Enzyme kinetics by mid-infrared spectroscopy: beta-fructosidase study by a one-step assay.
An alternate method for enzyme study is proposed. Multidimensional statistical analysis applied on mid-infrared attenuated total reflectance spectra (Cadet et al. (1991) Appl. Spectrosc. 42, 166-172)Expand
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Self-assembly of a diferrous triple-stranded helicate with bis(2,2'-bipyridine) ligands: thermodynamic and kinetic intermediates.
The protonation and iron(II) coordination properties of a bis(2,2'-bipyridine) ligand L were investigated in methanol. The protonated forms showed allosteric effects due to the flexibility of theExpand
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