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A mechanism-based classification of pain in multiple sclerosis
Pharmacological treatment of pain in multiple sclerosis (MS) is challenging due to the many underlying pathophysiological mechanisms. Few controlled trials show adequate pain control in thisExpand
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BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: Results from a phase II study
Methods: Four hundred and sixty-one adult subjects with migraine were randomised to one of five treatments, the oral antagonist at the calcitonin gene-related peptide (CGRP) receptor BI 44370 TA (50Expand
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Increased expression of dopamine receptors on lymphocytes in Parkinson's disease
Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjectsExpand
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Donepezil in the treatment of hallucinations and delusions in Parkinson’s disease
As cholinergic mechanisms may be at least partially responsible for hallucinations and delusions in Parkinson’s disease (PD), we conducted an open study in 8 PD patients to assess the efficacy andExpand
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Amitriptyline Is Effective in Chronic But Not in Episodic Tension‐Type Headache: Pathogenetic Implications
The tricyclic antidepressant amitriptyline, is an effective drug for the treatment of chronic tension‐type headache and for other chronic pain syndromes, but it is also effective in the prophylaxisExpand
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Dopamine hypersensitivity in migraine: role of the apomorphine test.
We investigated the effects of apomorphine administration at two different doses (2-10 micrograms/kg, s.c.) in 35 migraineurs in headache-free period and in 20 age-matched healthy control subjects,Expand
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Donepezil in the treatment of progressive supranuclear palsy
Objectives– To evaluate the effect of 3 month therapy with donepezil, a centrally acting cholinesterase inhibitor, on cognitive performances, motor function and daily living activities in progressiveExpand
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Excessive daytime sleepiness in de novo and treated Parkinson's disease
Excessive daytime sleepiness (EDS) in Parkinson's disease (PD) is due to either treatment‐related factors or the disease itself. The study of this disturbing phenomenon in de novo parkinsonianExpand
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Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's disease
Clinical and pathological evidence points to an involvement of dopamine in Alzheimer's disease (AD). The present study was designed to assay dopamine D1-like and D2-like receptors on peripheral bloodExpand
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Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study
BackgroundThe treatment of migraine headache is challenging given the lack of a standardized approach to care, unsatisfactory response rates, and medication overuse. Neuromodulation therapy hasExpand
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