P. B. Wigley

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Rapid expression of chemokines and proinflammatory cytokines in newly hatched chickens infected with Salmonella enterica serovar typhimurium.

G S K Withanage, Pete Kaiser, +7 authors Ian McConnell
Infection and immunity
2004

Poultry meat and eggs contaminated with Salmonella enterica serovar Enteritidis or Salmonella enterica serovar Typhimurium are common sources of acute gastroenteritis in humans. However, the exact… (More)

Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium.

Muhammad Iqbal, Victoria Jane Philbin, +10 authors Adrian P. L. Smith
Infection and immunity
2005

Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In… (More)

Characterisation of Salmonella enterica serotype Typhimurium isolates from wild birds in northern England from 2005 – 2006

Laura E. Hughes, Sara Shopland, +8 authors Julian C Chantrey
BMC veterinary research
2008

BACKGROUND Several studies have shown that a number of serovars of Salmonella enterica may be isolated from wild birds, and it has been suggested that wild birds may play a role in the epidemiology… (More)

Cytokine and chemokine responses associated with clearance of a primary Salmonella enterica serovar Typhimurium infection in the chicken and in protective immunity to rechallenge.

G S K Withanage, P. B. Wigley, +7 authors Ian McConnell
Infection and immunity
2005

Infection of poultry with Salmonella enterica serovar Typhimurium poses a significant risk to public health through contamination of meat from infected animals. Vaccination has been proposed to… (More)

The immunobiology of avian systemic salmonellosis.

Lucy C Chappell, Peter Kaiser, Paul Barrow, Michael A. Jones, Claire F Johnston, P. B. Wigley
Veterinary immunology and immunopathology
2009

Avian systemic salmonellosis is primarily caused by Salmonella enterica serovar Gallinarum and serovar Pullorum causing the diseases Fowl Typhoid and Pullorum Disease respectively. During infection… (More)

Campylobacter jejuni Is Not Merely a Commensal in Commercial Broiler Chickens and Affects Bird Welfare

Suzanne Humphrey, Gemma L. Chaloner, +5 authors P. B. Wigley
mBio
2014

Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models… (More)

Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes

Philip J. Hepworth, Kevin E. Ashelford, +12 authors Craig Winstanley
Environmental microbiology
2011

Although the major food-borne pathogen Campylobacter jejuni has been isolated from diverse animal, human and environmental sources, our knowledge of genomic diversity in C. jejuni is based… (More)

Invasive Non-Typhoidal Salmonella Typhimurium ST313 Are Not Host-Restricted and Have an Invasive Phenotype in Experimentally Infected Chickens

Bryony N Parsons, Suzanne Humphrey, +4 authors P. B. Wigley
PLoS neglected tropical diseases
2013

Salmonella enterica serovar Typhimurium Sequence Type (ST) 313 is a major cause of invasive non-Typhoidal salmonellosis in sub-Saharan Africa. No animal reservoir has been identified, and it has been… (More)

Macrophages isolated from chickens genetically resistant or susceptible to systemic salmonellosis show magnitudinal and temporal differential expression of cytokines and chemokines following…

P. B. Wigley, Scott D. Hulme, Lisa Rothwell, Nat Bumstead, Pete Kaiser, Paul Barrow
Infection and immunity
2006

Macrophages from inbred chickens that are resistant to salmonellosis show greater and more rapid expression of proinflammatory chemokines and cytokines, including the key Th1-inducing cytokine… (More)

Patterns of genome evolution that have accompanied host adaptation in Salmonella.

Gemma C. Langridge, Maria Fookes, +16 authors Nicholas R Thomson
Proceedings of the National Academy of Sciences…
2015

Many bacterial pathogens are specialized, infecting one or few hosts, and this is often associated with more acute disease presentation. Specific genomes show markers of this specialization, which… (More)

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