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Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist.
TLDR
Binding and functional studies performed over 40 different receptors revealed that LF 16-0687 was selective for the BK B2 receptor. Expand
Markedly different effects on ventricular remodeling result in a decrease in inducibility of ventricular arrhythmias.
TLDR
It is indicated that the inducibility of ventricular arrhythmias can be reduced as a result of markedly different effects on ventricular remodeling, indicating that the relation between ventricular renovation, arrh rhythmias and survival is more complex than previously thought. Expand
Pharmacological characterization of the bradykinin B2 receptor: inter‐species variability and dissociation between binding and functional responses
TLDR
The affinity values of BK derivatives as well as non‐peptide antagonists were reduced by 6–23 fold in physiological HBSS compared to low ionic strength TES binding buffer and the binding buffer composition has to be taken into account when screening new compounds. Expand
Effects of lipid-lowering drugs on left ventricular function and exercise tolerance in dyslipidemic coronary patients.
TLDR
A 12-week lipid-lowering treatment with either S or F did not negatively alter left ventricular function during exercise in dyslipidemic patients with established coronary heart disease and did not affect their ability to exercise. Expand
GeneUp: a program to select short PCR primer pairs that occur in multiple members of sequence lists.
TLDR
A computer program is presented that selects a small set of short primer pairs for PCR to sample all the sequences in a user-specified list of m RNAs to increase the probability of sampling mRNAs of particular interest in differential display and to generate simplified hybridization probes for DNA chips or arrays. Expand
Induction of kinin B1 receptor‐dependent vasoconstriction following balloon catheter injury to the rabbit carotid artery
TLDR
BK and its metabolite, des‐Arg9‐BK act as vasoconstrictor agents following balloon catheter injury and appear to be mediated by activation of B1 receptors. Expand
Pharmacological evidence for a single bradykinin B2 receptor in the guinea‐pig
TLDR
The results do not support the existence of a B3 receptor in the trachea and it is suggested that the previously reported B2B receptor subtype simply represents the guinea‐pig isoform. Expand
Inflammatory hyperalgesia induced by zymosan in the plantar tissue of the rat: effect of kinin receptor antagonists.
TLDR
Zymosan-induced hyperalgesia is a model suitable for the rapid evaluation of analgesic drugs with a peripheral site of action interfering either with kinin receptors or with prostanoid formation and results of the present study confirm that blocking kinin B1 receptors is a novel approach for treatment of inflammatory pain. Expand
Design and synthesis of potent bradykinin agonists containing a benzothiazepine moiety.
TLDR
Evidence is provided for a bioactive conformation of bradykinin constrained at the dipeptide Pro-Phe, as well as for a concentration-dependent phosphoinositide production in CHO cells expressing the human cloned B(2) receptor. Expand
Haemodynamic and cardiac effects of kinin B1 and B2 receptor stimulation in conscious instrumented dogs
TLDR
The results suggest that prostanoids are not involved in the vascular response to kinins and that coronary vascular B1 receptors are at least in part coupled to the release of NO. Expand
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