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The OmpA-Like Protein Loa22 Is Essential for Leptospiral Virulence
TLDR
Loa22 is necessary for virulence of L. interrogans in the animal model and represents the first genetically defined virulence factor in Leptospira species, according to predicted OmpA domain based on sequence identity.
High Levels of Viral Replication during Primary Simian Immunodeficiency Virus SIVagm Infection Are Rapidly and Strongly Controlled in African Green Monkeys
TLDR
The results indicate that the nonpathogenic outcome of SIVagm infection in its natural host is associated with a rapidly induced control of viral replication in response to SIVAGm infection, rather than with a poorly replicating virus or a constitutive host genetic resistance to virus replication.
The regulation of zinc homeostasis by the ZafA transcriptional activator is essential for Aspergillus fumigatus virulence
TLDR
It is concluded that ZafA is a zinc‐responsive transcriptional activator that represents an essential attribute for A.’fumigatus pathogenicity and may constitute a new target for the development of chemotherapeutic agents against Aspergillus, because no zafA orthologues have been found in mammals.
An ex-vivo Human Intestinal Model to Study Entamoeba histolytica Pathogenesis
TLDR
An ex vivo human colon model to study the early steps in amoebiasis established that E. histolytica caused the removal of the protective mucus coat during the first two hours of incubation, detached the enterocytes, and then penetrated into the lamina propria by following the crypts of Lieberkühn.
Production of phthiocerol dimycocerosates protects Mycobacterium tuberculosis from the cidal activity of reactive nitrogen intermediates produced by macrophages and modulates the early immune
TLDR
It is suggested that DIM production contributes to the initial growth of M. tuberculosis by protecting it from the nitric oxide‐dependent killing of macrophages and modulating the early immune response to infection.
Isolation and Characterization of New Leptospira Genotypes from Patients in Mayotte (Indian Ocean)
TLDR
Typing of leptospiral isolates showed that causative agents ofLeptospirosis in Mayotte have unique molecular features, suggesting that the strains were novel serovars.
Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis
TLDR
It is shown that the addition of propionate to cell culture medium enhanced the ability of alveolar macrophages to kill methylcitrate synthase mutant but not wild‐type conidia, which provides a suitable target for new antifungals.
The parasite Entamoeba histolytica exploits the activities of human matrix metalloproteinases to invade colonic tissue.
TLDR
The results suggest that MMP-3 and/or CP-A5 inhibitors may be of value in further studies aiming to treat intestinal amoebiasis.
Transferrin is an early marker of hepatic differentiation, and its expression correlates with the postnatal development of oligodendrocytes in mice
TLDR
The results indicate that Tf gene expression correlates with the postnatal development of oligodendrocytes in the mouse CNS, and may be an important tool to follow the hepatic specification of the gut endoderm.
Macrophage subsets harbouring Leishmania donovani in spleens of infected BALB/c mice: localization and characterization
TLDR
In the spleens of L. donovani‐infected mice, a high percentage of amastigotes are located in macrophage expressing MHC class II molecules and that they live in PV exhibiting properties similar to those of PV detected in mouse bone marrow‐derived macrophages exposed to a low dose of interferon γ (IFN‐γ) and infected in vitro.
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