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Guidelines for the Care and Welfare of Cephalopods in Research –A consensus based on an initiative by CephRes, FELASA and the Boyd Group
This paper is the result of an international initiative and is a first attempt to develop guidelines for the care and welfare of cephalopods following the inclusion of this Class of ∼700 known living invertebrate species in Directive 2010/63/EU. Expand
Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program.
This randomized clinical trial tested whether paroxetine, a selective serotonin reuptake inhibitor antidepressant known to modulate brain serotonin, would reduce fatigue in cancer patients and whether any reduction was related to depression. Expand
Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin.
It is suggested that both ghrelin and motilin can regulate intestinal motility in zebrafish and most likely other teleosts, and are discussed in relation to the evolution of these regulatory peptides. Expand
Neuropharmacology of emesis induced by anti-cancer therapy.
A sequence of events, evoked by anti-cancer therapies, are suggested, which could form the basis for further experimental investigation of the neuropharmacology of vomiting. Expand
Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
Understanding the central processing of signals for nausea and vomiting is particularly problematic in the light of observations that vomiting is more readily amenable to pharmacological treatment than is nausea, despite the assumption that nausea represents "low" intensity activation of pathways that can evoke vomiting when stimulated more intensely. Expand
Nausea: Mechanisms and Management
Nausea is a complex sensation that results from the interaction of certain fixed biological factors, such as gender, with changeable psychological factors, such as anxiety. This is the first book toExpand
The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity.
Preliminary evidence is presented here that there may be a degree of plasticity in the emetic pathway following such lesions that is more sensitive than other species and for radiation it appears to be the most sensitive of the laboratory animals studied. Expand
Vagal afferent discharge from mechanoreceptors in different regions of the ferret stomach.
It is concluded that the properties of the tension receptor are determined by their site in the stomach and this physical property together with neurally mediated receptive relaxation of the corpus is the reason for the fluid distribution described above. Expand
Treatment of nausea and vomiting: Gaps in our knowledge
The unmet clinical need to adequately control nausea, possibly by new drugs acting within the brainstem, and the significant gaps in understanding key aspects of the emetic reflex, suggest an important need to focus and re-direct research into the distressing and sometimes life-threatening symptoms of nausea and vomiting. Expand
Fundamentals of neurogastroenterology
Psychologic and psychiatric relations to functional gastrointestinal disorders are included because they are significant components of neurogastroenterology, especially in relation to projections of discomfort and pain to the digestive tract. Expand