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Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
Nausea and vomiting are amongst the most common symptoms encountered in medicine as either symptoms of diseases or side effects of treatments. In a more biological setting they are also importantExpand
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Nausea: Mechanisms and Management
Nausea is a complex sensation that results from the interaction of certain fixed biological factors, such as gender, with changeable psychological factors, such as anxiety. This is the first book toExpand
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The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity.
In recent years the role of the area postrema in the emetic reflex has been predominant and the involvement of the abdominal visceral innervation has tended to be overlooked. This paper attempts toExpand
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Neuropharmacology of emesis induced by anti-cancer therapy.
Abstract Cancer patients receiving certain cytotoxic therapies can experience severe nausea and vomiting, lasting for up to five days. Conventional antiemetic treatments may be poorly effective orExpand
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The identification and management of pain, suffering and distress in cephalopods, including anaesthesia, analgesia and humane killing
Abstract From January 2013 scientific projects involving cephalopods became regulated by Directive 2010/63/EU, but at present there is little guidance specifically for cephalopods on a number of keyExpand
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Resinferatoxin, an ultrapotent capsaicin analogue, has anti-emetic properties in the ferret
Resinferatoxin (100 micrograms/kg, s.c.), the ultrapotent analogue of capsaicin, when given acutely blocked radiation-(200 rads) and copper sulphate (40 mg% 30 ml, p.o.)-induced emesis in ferrets andExpand
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Treatment of nausea and vomiting: Gaps in our knowledge
The past 20 years have seen notable advances in our understanding of the physiology and pharmacology of the emetic reflex leading to the identification of the anti-emetic effects ofExpand
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Vagal afferent discharge from mechanoreceptors in different regions of the ferret stomach.
1. The rate and volume of gastric filling was estimated in conscious ferrets by measuring the amount of milk they would drink after an overnight fast. The mean volume was 94.5 +/‐ 7.5 ml. at a rateExpand
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Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats.
This study aimed to dissect the mechanisms involved in malaise induced by the anti-cancer drug cisplatin by attempting to uncouple its effects on locomotor activity, arguably at least partlyExpand
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The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK1 receptor
1 The selective NK1 receptor antagonist, CP‐99,994, produced dose‐related (0.1‐1.0 mg kg−1, s.c.) inhibition of vomiting and retching in ferrets challenged with central (loperamide and apomorphine),Expand
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