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Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
Nausea and vomiting are amongst the most common symptoms encountered in medicine as either symptoms of diseases or side effects of treatments. In a more biological setting they are also important… Expand
Nausea: Mechanisms and Management
Nausea is a complex sensation that results from the interaction of certain fixed biological factors, such as gender, with changeable psychological factors, such as anxiety. This is the first book to… Expand
The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity.
- P. Andrews, C. J. Davis, S. Bingham, H. M. Davidson, J. Hawthorn, L. Maskell
- Canadian journal of physiology and pharmacology
- 1 February 1990
In recent years the role of the area postrema in the emetic reflex has been predominant and the involvement of the abdominal visceral innervation has tended to be overlooked. This paper attempts to… Expand
Neuropharmacology of emesis induced by anti-cancer therapy.
Abstract Cancer patients receiving certain cytotoxic therapies can experience severe nausea and vomiting, lasting for up to five days. Conventional antiemetic treatments may be poorly effective or… Expand
The identification and management of pain, suffering and distress in cephalopods, including anaesthesia, analgesia and humane killing
Abstract From January 2013 scientific projects involving cephalopods became regulated by Directive 2010/63/EU, but at present there is little guidance specifically for cephalopods on a number of key… Expand
Resinferatoxin, an ultrapotent capsaicin analogue, has anti-emetic properties in the ferret
Resinferatoxin (100 micrograms/kg, s.c.), the ultrapotent analogue of capsaicin, when given acutely blocked radiation-(200 rads) and copper sulphate (40 mg% 30 ml, p.o.)-induced emesis in ferrets and… Expand
Treatment of nausea and vomiting: Gaps in our knowledge
The past 20 years have seen notable advances in our understanding of the physiology and pharmacology of the emetic reflex leading to the identification of the anti-emetic effects of… Expand
Vagal afferent discharge from mechanoreceptors in different regions of the ferret stomach.
1. The rate and volume of gastric filling was estimated in conscious ferrets by measuring the amount of milk they would drink after an overnight fast. The mean volume was 94.5 +/‐ 7.5 ml. at a rate… Expand
Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats.
- Nasser M Malik, Y. Liu, N. Cole, G. Sanger, P. Andrews
- European journal of pharmacology
- 26 January 2007
This study aimed to dissect the mechanisms involved in malaise induced by the anti-cancer drug cisplatin by attempting to uncouple its effects on locomotor activity, arguably at least partly… Expand
The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK1 receptor
1 The selective NK1 receptor antagonist, CP‐99,994, produced dose‐related (0.1‐1.0 mg kg−1, s.c.) inhibition of vomiting and retching in ferrets challenged with central (loperamide and apomorphine),… Expand