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A novel human volunteer pain model using contact heat evoked potentials (CHEP) following topical skin application of transient receptor potential agonists capsaicin, menthol and cinnamaldehyde
The discovery of transient receptor potential (TRP) receptors has advanced understanding of temperature sensation, and pre-clinical studies have identified TRP as major novel analgesic targets inExpand
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Role of the Nlrp3 Inflammasome in Microbial Infection
The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or dangerExpand
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Reduced vitamin D levels in painful diabetic peripheral neuropathy
Recent studies have reported an association between low vitamin D levels and diabetic peripheral neuropathy. However, many of these did not differentiate between people with painful diabeticExpand
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Bipedal locomotion of bonnet macaques after spinal cord injury.
Experimental studies concerning the analysis of locomotor behavior in spinal cord injury research are widely performed in rodent models. The purpose of this study was to quantitatively evaluate theExpand
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Targeting NLRP6 to enhance immunity against bacterial infections.
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Immunity to uropathogens: the emerging roles of inflammasomes
Urinary tract infections (UTIs) cause a huge burden of morbidity worldwide with recurrent UTIs becoming increasingly frequent owing to the emergence of antibiotic-resistant bacterial strains.Expand
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Integrating Inflammasome Signaling in Sexually Transmitted Infections
Inflammasomes are cytosolic multiprotein platforms with pivotal roles in infectious diseases. Activation of inflammasomes results in proinflammatory cytokine signaling and pyroptosis. SexuallyExpand
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Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation
Cellular lipids determine membrane integrity and fluidity and are being increasingly recognized to influence immune responses. Cellular cholesterol requirements are fulfilled through biosynthesis andExpand
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Cannabinoid receptor CB1-immunoreactive nerve fibres in painful and non-painful human tooth pulp
The cannabinoid receptor CB1 is involved in modulation of neuronal hypersensitivity and pain. The aim of this study was to evaluate CB1 receptor levels for the first time in dental pain. A total ofExpand
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Common Differences: The Ability of Inflammasomes to Distinguish Between Self and Pathogen Nucleic Acids During Infection.
The innate immune system detects the presence of pathogens based on detection of non-self. In other words, most pathogens possess intrinsic differences that can distinguish them from host cells. ForExpand
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