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Genetic studies of body mass index yield new insights for obesity biology
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
TREM2 variants in Alzheimer's disease.
- R. Guerreiro, Aleksandra M. Wojtas, J. Hardy
- Biology, PsychologyThe New England journal of medicine
- 10 January 2013
Heterozygous rare variants in TREM2 are associated with a significant increase in the risk of Alzheimer's disease.
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
A large genome-wide association study of 2,032 individuals from France with Alzheimer's disease and 5,328 controls identified other risk loci, which support roles of CLU and CR1 in the clearance of β amyloid (Aβ) peptide, the principal constituent of amyloids plaques, which are one of the major brain lesions of individuals with Alzheimer’s disease.
Common variants in ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease
Meta-analyses of all data provided compelling evidence that ABCA7 and the MS4A gene cluster are new Alzheimer's disease susceptibility loci and independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance.
Defining the role of common variation in the genomic and biological architecture of adult human height
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
Large-scale association analysis identifies new risk loci for coronary artery disease
An association analysis in CAD cases and controls identifies 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants strongly associated with CAD at a 5% false discovery rate (FDR).
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and…
New genetic loci link adipose and insulin biology to body fat distribution
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
It is reported that the DD genotype, which is associated with higher levels of circulating ACE than the ID and II genotypes, is significantly more frequent in patients with myocardial infarction than in controls, especially among subjects with low body-mass index and low plasma levels of ApoB.