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Structure, conformation and biological activity of a novel lipodepsipeptide from Pseudomonas corrugata: cormycin A.
TLDR
The structure of a novel lipodepsipeptide, cormycin A, produced in culture by the tomato pathogen Pseudomonas corrugata was elucidated by combined protein chemistry, mass spectrometry and two-dimensional NMR procedures, suggesting that c Cormycin derivatives could find promising applications, either as antifungal compounds for topical use or as post-harvest biocontrol agents.
Probing the dimeric structure of porcine aminoacylase 1 by mass spectrometric and modeling procedures.
TLDR
Results indicate that reliable approaches such as limited proteolysis, selective chemical modification, and cross-linking coupled to mass spectrometry can be used to test and optimize molecular models of multimeric proteins and highlight problems in automatic model building.
A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin.
TLDR
It is described how molecular oligomerization in aqueous solution can generate a still unknown transport form for amphipathic peptides, which is more compact and resistant to proteases than forms related to any possible monomer.
Structural determination of the active site of a sweet protein A 1H NMR investigation of pMNEI
TLDR
The detailed three‐dimensional structure of the loop (Tyr66‐Ala67‐Ser68‐Asp69) shows that the side chains or Tyr66 and Asp69 fit the model of the sweet receptor in a manner very similar to that of the side Chains of Phe and AsP or aspartame.
Rare casbane diterpenoids from the Hainan soft coral Sinularia depressa.
TLDR
A series of nine casbane diterpenes, compounds 5-13, exhibiting either cis or trans ring junctions were isolated from the Hainan soft coral Sinularia depressa and the structures of this group of compounds were established by detailed spectroscopic analysis.
Structural Determinants of Salmon Calcitonin Bioactivity
TLDR
The structural and biological data identify well defined structural parameters of the helix for sCT bioactivity, including the correct helix length, which requires long range interactions and the presence of specific regions of residues within the sequence for high binding affinity and hypocalcemic activity.
Topology of the calmodulin-melittin complex.
TLDR
The results show that melittin interacts with calmodulin by adopting a parallel orientation, providing this protein with the capability of regulating an even larger number of enzymes.
Solution structure of human calcitonin in membrane‐mimetic environment: The role of the amphipathic helix
TLDR
The 32 amino acid hormone human calcitonin was studied by multidimensional NMR spectroscopy in sodium dodecyl sulfate micelles at 310K and the relevance of the amphipathic helix for the structure–activity relationship, the possible mechanisms of interaction with the receptor, as well as the formation of fibrillar aggregates is discussed.
New role for leucyl aminopeptidase in glutathione turnover.
TLDR
A manganese-dependent cysteinyl-glycine hydrolysing activity has been purified to electrophoretic homogeneity from bovine lens and a new role for this enzyme in glutathione turnover is proposed.
Structural features of distinctin affecting peptide biological and biochemical properties.
TLDR
These experiments demonstrate that the simultaneous occurrence of both peptide chains and the disulfide bond is essential for the formation of the quaternary structure of distinctin in aqueous media, able to resist protease action.
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