Proteome survey reveals modularity of the yeast cell machinery
This study reports the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectrometry and provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling.
Relation between amino acid composition and cellular location of proteins.
A correlation analysis of the amino acid composition and the cellular location of a protein is presented and a program (ProtLock) to predict the cellular where a protein has been designed is designed.
A Proteome-Scale Map of the Human Interactome Network
A reference map of the human binary protein interactome
The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.
Interrogating protein interaction networks through structural biology
A method to test putative interactions on complexes of known 3D structure is described and confirmation for several interactions is provided, in addition to suggesting molecular details of how they occur.
Interactome3D: adding structural details to protein networks
The value of Interactome3D is illustrated through the structural annotation of the complement cascade pathway, rationalizing a potential common mechanism of action suggested for several disease-causing mutations.
Ten thousand interactions for the molecular biologist
This work uses protein interaction data from different sources and three-dimensional structures to suggest that the total number of interaction types in nature is limited, and estimates that most interactions in nature will conform to one of about 10,000 types.
The relationship between sequence and interaction divergence in proteins.
Structural systems biology: modelling protein interactions
Structural details can ultimately turn abstract system representations into models that more accurately reflect biological reality and help to predict the behaviour of biological systems.
3did: a catalog of domain-based interactions of known three-dimensional structure
- Roberto Mosca, A. Céol, Amelie Stein, R. Olivella, P. Aloy
- BiologyNucleic Acids Res.
- 28 September 2013
The database of 3D interacting domains (3did), available online for browsing and bulk download at http://3did.irbbarcelona.org, is a reference source of information for the structural characterization of protein interaction networks.