• Publications
  • Influence
Rab‐interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes
Rab7 is a small GTPase that controls transport to endocytic degradative compartments. Here we report the identification of a novel 45 kDa protein that specifically binds Rab7GTP at its C‐terminus.Expand
  • 421
  • 57
Histidine biosynthetic pathway and genes: structure, regulation, and evolution.
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L. Califano,’’ Universita degli Studi diExpand
  • 222
  • 25
  • PDF
The Neisseria meningitidis Capsule Is Important for Intracellular Survival in Human Cells
ABSTRACT While much data exist in the literature about how Neisseria meningitidis adheres to and invades human cells, its behavior inside the host cell is largely unknown. One of the essentialExpand
  • 148
  • 14
  • PDF
Functional Characterization of Rab7 Mutant Proteins Associated with Charcot-Marie-Tooth Type 2B Disease
Charcot-Marie-Tooth (CMT) type 2 neuropathies are a group of autosomal-dominant axonal disorders genetically and clinically heterogeneous. In particular, CMT type 2B (CMT2B) neuropathies areExpand
  • 140
  • 13
  • PDF
Nucleotide sequences of the genes regulating O-polysaccharide antigen chain length (rol) from Escherichia coli and Salmonella typhimurium: protein homology and functional complementation.
In this article, we report on the nucleotide sequences of the rol genes of Escherichia coli O75 and Salmonella typhimurium LT2. The rol gene in E. coli was previously shown to encode a 36-kDa proteinExpand
  • 100
  • 9
Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
We have determined the complete nucleotide sequence of the histidine operons of Escherichia coli and of Salmonella typhimurium. This structural information enabled us to investigate the expressionExpand
  • 122
  • 8
Whole-genome organization and functional properties of miniature DNA insertion sequences conserved in pathogenic Neisseriae.
The chromosome of pathogenic Neisseriae is peppered by members of an abundant family of small DNA sequences known as Correia elements. These DNA repeats, that we call nemis (for neisseria miniatureExpand
  • 62
  • 7
Ribonuclease E provides substrates for ribonuclease P-dependent processing of a polycistronic mRNA.
The polycistronic mRNA of the histidine operon is subject to a processing event that generates a rather stable transcript encompassing the five distal cistrons. The molecular mechanisms by which suchExpand
  • 139
  • 6
Hypermutation in pathogenic bacteria: frequent phase variation in meningococci is a phenotypic trait of a specialized mutator biotype.
Expression of serogroup B meningococcal capsular polysaccharide undergoes frequent phase variation involving reversible frameshift mutations within a homopolymeric repeat in the siaD gene. A highExpand
  • 119
  • 5
Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst
Polymorphonuclear neutrophil leucocytes (PMNs) are a critical part of innate immune defence against bacterial pathogens, and only a limited subset of microbes can escape killing by these phagocyticExpand
  • 27
  • 5