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Novel ω-Conotoxins from Conus catus Discriminate among Neuronal Calcium Channel Subtypes*
In electrophysiological studies, ω-conotoxins CVID and MVIIA had similar potencies to inhibit current through central and peripheral splice variants of the rat N-type calcium channels when coexpressed with rat β3 in Xenopus oocytes, but the potency of CVID increased when α1B-d and α1b-b were expressed in the absence of ratβ3.
Molecular Dissection of the Munc18c/Syntaxin4 Interaction: Implications for Regulation of Membrane Trafficking
Munc18c interacts with its cognate SNAREs in a manner that resembles the yeast proteins Sly1p and Sed5p rather than the mammalian neuronal proteins Munc18a and syntaxin1a, suggesting that Munc 18c could play a positive regulatory role in SNARE assembly.
Probing the S100 protein family through genomic and functional analysis.
AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity
A binding assay based on acetylcholine‐binding protein (AChBP) is used to discover a novel α‐conotoxin (α‐TxIA) in the venom of Conus textile, establishing a new pharmacophore for the design of novel subtype‐selective ligands with therapeutic potential in nAChR‐related diseases.
In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences.
Simple, effective protocols have been developed for manual and machine-assisted Boc-chemistry solid phase peptide synthesis on polystyrene resins. These use in situ neutralization [i.e.…
Ancient Venom Systems: A Review on Cnidaria Toxins
The complexity of venom components represents a unique therapeutic challenge and probably reflects the ancient evolutionary history of the cnidarian venom system and is invaluable as a therapeutic target for sting treatment or as lead compounds for drug design.
Deep Venomics Reveals the Mechanism for Expanded Peptide Diversity in Cone Snail Venom*
- S. Dutertre, A. Jin, Q. Kaas, Alun Jones, P. Alewood, R. Lewis
- BiologyMolecular & Cellular Proteomics
- 14 November 2012
Comprehensive integration of transcriptomic and proteomic data revealed for the first time that the vast majority of the conopeptide diversity arises from a more limited set of genes through a process of variable peptide processing, which generatesconopeptides with alternative cleavage sites, heterogeneous post-translational modifications, and highly variable N- and C-terminal truncations.
Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails
It is proposed that defensive toxins, originally evolved in ancestral worm-hunting cone snails to protect against cephalopod and fish predation, have been repurposed in predatory venoms to facilitate diversification to fish and mollusk diets.
Discovery, synthesis, and structure-activity relationships of conotoxins.
Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena, and they continue to attract interest due to their high potency, bioavailability, and fewer concerns with…
Oxidation Regulates the Inflammatory Properties of the Murine S100 Protein S100A8*
It is shown that hypochlorite oxidizes the single Cys residue (Cys41) of S100A8, the major oxidant generated by activated neutrophils at inflammatory sites, and results implicate involvement of the myeloperoxidase system.