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Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide
The data indicate that NUDR is a repressor of the 5-HT1A receptor in raphe cells the function of which is abrogated by a promoter polymorphism, suggesting a novel transcriptional model in which the G(-1019) allele derepresses 5- HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide.
Why is depression more prevalent in women?
- P. Albert
- PsychologyJournal of Psychiatry & Neuroscience
- 1 July 2015
This editorial focuses on biological contributors that are experimentally tractable and may help to understand how and why depression is more prevalent in women and lead to better treatments.
5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association
Evidence that altered transcription of the 5-HT1A receptor can affect the serotonin system and limbic and cortical areas, leading to predisposition to depression is reviewed.
Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease
Cloning and expression of a rat D2 dopamine receptor cDNA
This receptor has been characterized on the basis of three criteria: the deduced amino-acid sequence which reveals that it is a member of the family of G-protein-coupled receptors; the tissue distribution of the mRNA which parallels that of the D2 dopamine receptor; and the pharmacological profile of mouse fibroblast cells transfected with the cDNA.
Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response.
- S. Lemonde, L. Du, D. Bakish, P. Hrdina, P. Albert
- Psychology, BiologyInternational Journal of Neuropsychopharmacology
- 1 December 2004
The results implicate the C(-1019)G 5- HT1A gene polymorphism as a potential marker for antidepressant response, suggesting a role for repression of the 5-HT1A genes.
The Dopamine D2 Receptor
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts.
Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.
RGS17/RGSZ2, a Novel Regulator of Gi/o, Gz, and Gq Signaling*
- Helen Mao, Qingshi Zhao, M. Daigle, M. Ghahremani, P. Chidiac, P. Albert
- BiologyJournal of Biological Chemistry
- 18 June 2004
RGS17 is a new RZ member that preferentially inhibits receptor signaling via Gi/o, Gz, and Gq over Gs to enhance cAMP-dependent signaling and inhibit calcium signaling.
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes
It is shown that the transcriptional regulator Deaf1 controls the expression of genes encoding PTAs in the pancreatic lymph nodes (PLNs), and lower PTA expression resulting from the alternative splicing of DEAF1 may contribute to the pathogenesis of type 1 diabetes.