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Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation.
TLDR
Reductions in cerebrovascular responsiveness to CO(2) that provoke an increase in the gain of the chemoreflex control of breathing may underpin breathing instability during central sleep apnea in patients with congestive heart failure and on ascent to high altitude. Expand
Integrative regulation of human brain blood flow
TLDR
Mechanisms regulating cerebral blood flow (CBF), with specific focus on humans, are reviewed and the following four key theses are corroborated: that cerebral autoregulation does not maintain constant perfusion through a mean arterial pressure range of 60–150 mmHg; that there is important stimulatory synergism and regulatory interdependence of arterial blood gases and blood pressure on CBF regulation. Expand
Regional brain blood flow in man during acute changes in arterial blood gases
TLDR
During alterations in arterial carbon dioxide and oxygen, the large arteries changed diameter and blood flow to the brainstem changed more than that to the cortex. Expand
Cerebral blood flow during exercise: mechanisms of regulation.
TLDR
This finding indicates that, during heavy exercise, CBF decreases despite the cerebral metabolic demand, and this reduced CBF duringheavy exercise lowers cerebral oxygenation and therefore may act as an independent influence on central fatigue. Expand
Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function
TLDR
TCD is an efficient tool to access blood velocities within the cerebral vessels, cerebral autoregulation, cerebrovascular reactivity to CO(2), and neurovascular coupling in both physiological states and in pathological conditions such as stroke and head trauma. Expand
Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing
TLDR
Regular aerobic‐endurance exercise is associated with higher MCAv in men aged 18–79 years, and the persistence of this finding in older endurance‐trained men may help explain why there is a lower risk of cerebrovascular disease in this population. Expand
Estimating Human Energy Expenditure
TLDR
The use of motion sensors is very promising in the measurement of EE, and has a number of advantages over the DLW method, and if used correctly, both heart rate and questionnaire methods may provide valuable estimates of EE. Expand
Influence of Changes in Blood Pressure on Cerebral Perfusion and Oxygenation
TLDR
The findings indicate that cerebral blood flow closely follows pharmacological-induced changes in blood pressure in otherwise healthy humans, and a finite slope of the plateau region does not necessarily imply a defective CA. Expand
Elevated Aerobic Fitness Sustained Throughout the Adult Lifespan Is Associated With Improved Cerebral Hemodynamics
TLDR
Findings highlight the importance of maintaining aerobic fitness throughout the lifespan given its capacity to improve cerebral hemodynamics in later-life. Expand
Neurovascular coupling in humans: Physiology, methodological advances and clinical implications
TLDR
New guidelines for standardizing the assessment of neurovascular coupling in humans are presented and the utility of new automated software for neurov vascular coupling is demonstrated, which provides the capacity for coalescing repetitive trials and time intervals into single contours and extracting numerous metrics. Expand
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