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Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein
Water rapidly crosses the plasma membrane of red blood cells (RBCs) and renal tubules through specialized channels. Although selective for water, the molecular structure of these channels is unknown.Expand
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Aquaporin CHIP: the archetypal molecular water channel.
Despite longstanding interest by nephrologists and physiologists, the molecular identities of membrane water channels remained elusive until recognition of CHIP, a 28-kDa channel-forming integralExpand
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Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.
A novel Mr 28,000 integral membrane protein ("28kDa") was identified in human erythrocytes and found entirely associated with the Triton X-100 insoluble membrane skeletons. Antibodies to 28kDaExpand
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Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat.
The molecular pathways for fluid transport in pulmonary, oral, and nasal tissues are still unresolved. Here we use immunocytochemistry and immunoelectron microscopy to define the sites of expressionExpand
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The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.
  • M. Lu, M. Lee, +6 authors P. M. Deen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 October 1996
The aquaporin family of membrane water transport proteins are expressed in diverse tissues, and in brain the predominant water channel protein is AQP4. Here we report the isolation andExpand
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Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat.
Developmental expression of aquaporin water transport proteins is not well understood in respiratory tract or secretory glands; here we define aquaporin protein ontogeny in rat. Expression ofExpand
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Differential control of band 3 lateral and rotational mobility in intact red cells.
Measurements of integral membrane protein lateral mobility and rotational mobility have been separately used to investigate dynamic protein--protein and protein-lipid interactions that underlieExpand
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Human red cell Aquaporin CHIP. II. Expression during normal fetal development and in a novel form of congenital dyserythropoietic anemia.
Channel-forming integral protein (CHIP) is the archetypal member of the Aquaporin family of water channels. Delayed CHIP expression was shown recently in perinatal rat (Smith, B. L., R. Baumgarten,Expand
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Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum.
Water transport during peritoneal dialysis (PD) requires ultrasmall pores in the capillary endothelium of the peritoneum and is impaired in the case of peritoneal inflammation. The water channelExpand
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Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance.
In the rat, aquaporin-6 (AQP6) is mainly localized in intercalated cells (ICs) in collecting ducts, where it is exclusively associated with intracellular vesicles. In this study, we examined whetherExpand
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