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TREATMENT OF PARACETAMOL (ACETAMINOPHEN) POISONING WITH N-ACETYLCYSTEINE
Fifteen patients with paracetamol (acetaminophen) poisoning were treated with intravenous N-acetylcystein (300 mg/kg given over 20 h), which was very well tolerated and has the advantage of being available as a pharmaceutical preparation in a 20% sterile solution. Expand
Paracetamol metabolism following overdosage: application of high performance liquid chromatography
- D. Howie, P. Adriaenssens, L. Prescott
- Chemistry, Medicine
- The Journal of pharmacy and pharmacology
- 1 September 1977
The pattern of urinary excretion of paracetamol metabolites did not appear to be influenced by the treatment given, but was related to the severity of liver damage (Table 1), which was significantly less in Patients with severe liver damage than in those without. Expand
Structure-activity analysis of a Conus peptide blocker of N-type neuronal calcium channels.
- L. Nadasdi, D. Yamashiro, D. Chung, K. Tarczy-Hornoch, P. Adriaenssens, J. Ramachandran
- Chemistry, Medicine
- 27 June 1995
Comparison of the binding of SNX-111 and its analogs to rat brain synaptosomal membranes rich in N-type channels revealed that, among the four lysines and two arginines in the molecule, lysine in position 2 and arginine at position 10 and 21 are important for the interaction of SNx-111 with N- type channels. Expand
Self-concept and physical self-concept in psychiatric children and adolescents.
- J. Simons, C. Capio, P. Adriaenssens, H. Delbroek, I. Vandenbussche
- Psychology, Medicine
- Research in developmental disabilities
- 1 May 2012
In the different diagnostic groups specific domains were affected in line with symptomatology, which has implications for therapy. Expand
Paracetamol metabolism in chronic liver disease
- J. Forrest, P. Adriaenssens, N. Finlayson, L. Prescott
- European Journal of Clinical Pharmacology
- 1 July 1979
The glutathione conjugation of paracetamol did not seem to be impaired in patients with severe liver disease as evidenced by the production of normal amounts of the cysteine and mercapturic acid conjugates, and there is thus no evidence that they are at increased risk of hepatotoxicity when given a single therapeutic dose of par acetamol. Expand
Inappropriate Methods for the Emergency Determination of Plasma Paracetamol
- M. J. Stewart, P. Adriaenssens, D. Jarvie, L. Prescott
- Annals of clinical biochemistry
- 1 January 1979
Methods for the estimation of plasma paracetamol which depend on acid hydrolysis to p-aminophenol without a prior extraction step also measure inactive metabolites which are present in high concentrations, and these non-specific methods should not be used to determine the need for specific therapy in patients with par acetamol poisoning. Expand
Audiovisual aid viewing immediately before pediatric induction moderates the accompanying parents’ anxiety
A large number of parents accompanying their child during induction of anesthesia experience stress and the impact of audiovisual aid (AVA) on parental state anxiety and assessment of the child’s anxiety at induction need closer scrutiny. Expand
High performance liquid chromatographic estimation of paracetamol metabolites in plasma.
Isolation and quantitation of DNA-bound benzo(a)pyrene metabolites: comparison of hydroxyapatite and precipitation procedures.
The hydroxyapatite procedure resulted in the isolation of purer DNA and required less time and sample handling than the precipitation method, and for isolation of DNA from whole tissue for carcinogen-DNA adduct analysis, these properties make the Hydroxyap atite procedure superior to the precipitation procedure. Expand
A micromethod for the emergency estimation of plasma paracetamol concentration using high performance liquid chromatography.
- T. Buchanan, P. Adriaenssens, M. J. Stewart
- Chemistry, Medicine
- Clinica chimica acta; international journal of…
- 3 December 1979
A method has been developed for the emergency estimation of paracetamol using high performance liquid chromatography and the use of a micro-centrifuge reduces the total time for the estimation to 5 min from the receipt of the blood specimen. Expand