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Man-made cytotoxic steroids: exemplary agents for cancer therapy.
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Synthesis and antileukemic activity of 16E-[4-(2-carboxy)ethoxybenzylidene]-androstene amides
In order to determine the structural requirements for cytotoxicity against various tumor cell lines, a new series of 16E-arylidene androstene amides with varying degrees of unsaturation in ring A hasExpand
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Synthesis of androstene oxime-nitrogen mustard bioconjugates as potent antineoplastic agents
&NA; In the present study, synthesis and antineoplastic activity of phenylacetic acid and benzoic acid nitrogen mustard conjugates of various steroidal oximes are reported for the first time. TheExpand
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Hybrids of Steroid and Nitrogen Mustard as Antiproliferative Agents: Synthesis, In Vitro Evaluation and In Silico Inverse Screening.
Hybrids of 16E-arylidene steroids and nitrogen mustard have been synthesized and evaluated for their in vitro cytotoxic activity to develop tissue specific antineoplastic agents from steroids. TheseExpand
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Synthesis and Antiproliferative Activity of Some Androstene Oximes and Their O‐Alkylated Derivatives
In order to study the structure–activity relationship with respect to the cytotoxicity of steroidal oximes, several 6E‐hydroximino‐4‐ene steroids and their O‐alkylated derivatives were synthesized.Expand
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Role of Salt Selection in Drug Discovery and Development
Abstract Most of the drugs developed in the recent years originally remain as a weak base or acid, but drugs in these forms usually have undesirable pharmaceutical characteristics. PharmaceuticalExpand
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Solubility and Solubilization Approaches in Pharmaceutical Product Development
Abstract The intensive efforts undertaken to get effective drugs have resulted in the generation of candidates with unfavorable properties, i.e., greater lipophilicity, high molecular weightExpand
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Crystal and Molecular Structure and DFT Calculations of the Steroidal Oxime 6E-Hydroximino-androst-4-ene-3,17-dione (C19H25NO3) a Molecule with Antiproliferative Activity
The single crystal X-ray structure of the novel steroid derivative, 6E-hydroximino-androst-4-ene-3,17-dione (C19H25NO3) (code name RB-499), possessing antiproliferative activity against various cellExpand
Targeting Cancer through Angiogenesis Inhibition: Prospective of Azole Based Small Molecules
Anticancer drug discovery is a major focus area in the pharmaceutical industry and obtaining targeted drug molecules for the malignant tissue is a major hurdle in this process. With the advancementExpand
Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy
A highly stereoselective, one-pot, multicomponent method has been developed to synthesize pyrrolizidine- and N-methyl pyrrolidine-substituted spirooxindole derivatives. The [3 + 2] cycloadditionExpand