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Chronic Wound Repair and Healing in Older Adults: Current Status and Future Research
Older adults are more likely to have chronic wounds than younger people, and the effect of chronic wounds on quality of life is particularly profound in this population. Wound healing slows with age,Expand
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Angiotensin II Type 2 Receptor–Bradykinin B2 Receptor Functional Heterodimerization
Angiotensin II type 2 (AT2R) or bradykinin B2 (B2R) receptor activation enhances NO production. Recently, we demonstrated enhancement of NO production when AT2R and B2R are simultaneously activatedExpand
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The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance
Aging is associated with the accumulation of various deleterious changes in cells. According to the free radical and mitochondrial theory of aging, mitochondria initiate most of the deleteriousExpand
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Intrinsic Aerobic Capacity Sets a Divide for Aging and Longevity
Rationale: Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poorExpand
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Angiotensin AT2 Receptors Directly Stimulate Renal Nitric Oxide in Bradykinin B2-Receptor–Null Mice
Abstract—Both bradykinin B2 and angiotensin II type 2 (AT2) receptors are known to stimulate renal production of nitric oxide (NO). To evaluate the individual contributions of AT2 and B2 receptors toExpand
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The Angiotensin II Type 1 Receptor Mediates Renal Interstitial Content of Tumor Necrosis Factor-α in Diabetic Rats
A unique microdialysis technique was used to demonstrate that increased levels of angiotensin II (Ang II) and consequent stimulation of the Ang II type 1 (AT1) receptor increase the renal content ofExpand
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Dual Peptide Conjugation Strategy for Improved Cellular Uptake and Mitochondria Targeting
Mitochondria are critical regulators of cellular function and survival. Delivery of therapeutic and diagnostic agents into mitochondria is a challenging task in modern pharmacology because theExpand
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Topical Reformulation of Valsartan for Treatment of Chronic Diabetic Wounds.
Chronic wounds are among the most devastating and difficult to treat consequences of diabetes. Dysregulation of the skin renin-angiotensin system is implicated in abnormal wound healing in diabeticExpand
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When Doctors and Daughters Disagree: Twenty‐Two Days and Two Blinks of an Eye
A cornerstone of American medical ethics is the right to say, “Keep your hands off of me,” to decline medical treatment. A central problem is how to decide about individuals who have becomeExpand
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Angiotensin Subtype-2 Receptors Inhibit Renin Biosynthesis and Angiotensin II Formation
Renin is regulated by angiotensin subtype 1 (AT1) receptor, but it is unknown whether angiotensin subtype 2 (AT2) receptor contributes to this regulation. We hypothesized that AT2 receptors inhibitExpand
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