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Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives
NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a seriesExpand
Enzymatic synthesis of new C-6-acylated derivatives of NAG-thiazoline and evaluation of their inhibitor activities towards fungal β-N-acetylhexosaminidase
Abstract β- N -Acetylhexosaminidases (EC 3.2.1.52) from the CAZy glycoside hydrolase families 20 and 84 are two distinct enzyme groups with similar reactivity and different physiological functions,Expand
Utilizing terpene derivatives in the synthesis of annulated terpene-imidazoles with application in the nitroaldol reaction
Abstract Two classes of terpene derivatives (diketones and monoximes) were condensed into annulated terpene-imidazoles using two general methods. Method A, involving the condensation of terpeneExpand
Monomeric organoantimony(I) and organobismuth(I) compounds stabilized by an NCN chelating ligand: syntheses and structures.
The synthesis and structure of compounds containing multiple bonds between heavier Group 15 (Sb, Bi) elements, or analogous low-valent compounds with the central atom in the formal oxidation state +Expand
[1]Benzofuro[3,2-c]pyridine synthesis and coordination reactions
Abstract(E)-3-(1-Benzofuran-2-yl)propenoic acid (1) was prepared from 1-benzofuran-2-carbaldehyde under the Doebner’s conditions. The obtained acid was converted to the corresponding azide 2, whichExpand
Oxidative Addition of Diphenyldichalcogenides PhEEPh (E = S, Se, Te) to Low-Valent CN- and NCN-Chelated Organoantimony and Organobismuth Compounds
The reactions of the organoantimony(I) compound L14Sb4 (1) (where L1 = [o-C6H4(CH═NC6H3(i-Pr)2-2,6)]) with diphenyldichalcogenides PhEEPh (E = S, Se, or Te) gave compounds L1Sb(EPh)2 (E = S (2), SeExpand
On the Reduction of NC Chelated Organoantimony(III) Chlorides
The conversion of organolithium compound LLi, for which L = [o-C6H4(CH=NC6H3iPr2-2,6)]–, with antimony chloride gave the molecular chlorides LSbCl2 (1) and L2SbCl (2) depending on the molar ratioExpand
Oxidative addition of organic disulfides to low valent N,C,N-chelated organobismuth(I) compound: Isolation, structure and coordination capability of substituted bismuth(III) bis(arylsulfides)
Abstract The reaction between in situ prepared THF solution of N,C,N-chelated organobismuth(I) [LBi]n compound (not isolated), via reaction of LBiCl2 (1) (where L = [o,o-C6H3(CH2NMe2)2]) withExpand
Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non‐nucleoside reverse transcriptase inhibitors
With the worldwide number of human immunodeficiency virus positive patients stagnant and the increasing emergence of viral strains resistant to current treatment, the development of novel anti-humanExpand
The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor
Patients deficient in purine nucleoside phosphorylase (PNP), show marked impairment in T-cell immune function but normal to elevated B-cell function [1], The mechanism for this deficiency involves aExpand
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