Long-Term Cold Acclimation Extends Survival Time at 0°C and Modifies the Metabolomic Profiles of the Larvae of the Fruit Fly Drosophila melanogaster
- V. Košťál, Jaroslava Korbelová, P. Šimek
- BiologyPLoS ONE
- 21 September 2011
It is found that long-term cold acclimation considerably improved cold tolerance in fully grown third-instar larvae of D. melanogaster and showed metabolic potential for the accumulation of proline and trehalose and for membrane restructuring.
Hyperprolinemic larvae of the drosophilid fly, Chymomyza costata, survive cryopreservation in liquid nitrogen
- V. Košťál, H. Zahradníčková, P. Šimek
- BiologyProceedings of the National Academy of Sciences
- 25 July 2011
Increased the levels of proline in the larval tissues by feeding larvae proline-augmented diets and found that this simple treatment dramatically improved their freeze tolerance, providing direct evidence for the essential role of prolines in high freeze tolerance.
Effects of acclimation temperature on thermal tolerance and membrane phospholipid composition in the fruit fly Drosophila melanogaster.
- J. Overgaard, A. Tomčala, V. Košťál
- Biology, Environmental ScienceJournal of insect physiology
- 1 March 2008
Conversion of the chill susceptible fruit fly larva (Drosophila melanogaster) to a freeze tolerant organism
- V. Košťál, P. Šimek, H. Zahradníčková, J. Cimlová, T. Štětina
- BiologyProceedings of the National Academy of Sciences
- 13 February 2012
It is shown that surprisingly simple laboratory manipulations can change the chill susceptible insect to the freeze tolerant one.
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
- R. Vaclavikova, P. Souček, I. Gut
- Biology, ChemistryDrug Metabolism And Disposition
- 1 June 2004
The metabolism of docetaxel is the same in all four species, but metabolism of paclitaxe is different, and 6 alpha-OHP remains a uniquely human metabolite.
Cryoprotective role of polyols independent of the increase in supercooling capacity in diapausing adults of Pyrrhocoris apterus (Heteroptera: Insecta).
- V. Kost'ál, M. Šlachta, P. Šimek
- Biology, Environmental ScienceComparative Biochemistry and Physiology Part B…
- 1 October 2001
A novel R2R3 MYB transcription factor NtMYBJS1 is a methyl jasmonate-dependent regulator of phenylpropanoid-conjugate biosynthesis in tobacco.
- I. Galis, P. Šimek, K. Matsuoka
- BiologyThe Plant Journal
- 1 May 2006
Results of both antisense expression analysis and of gel mobility shift assays strongly indicate that the NtMYBJS1 protein functions in tobacco MJ signal transduction, inducing phenylpropanoid biosynthetic genes and the accumulation of phenyl Propanoid-polyamine conjugates during stress.
Identification of xanthine and hypoxanthine as components of assembly pheromone in excreta of argasid ticks
- F. Dusbábek, P. Šimek, A. Jegorov, J. Tříska
- ChemistryExperimental & applied acarology
- 1 August 1991
In addition to guanine, xanthine and hypoxanthine were identified in white spherules in excreta of five species ofArgas andOrnithodoros ticks by a reverse-phase high-performance liquid chromatography…
A new member of the AKH/RPCH family that stimulates locomotory activity in the firebug, Pyrrhocoris apterus (Heteroptera).
- D. Kodrík, R. Socha, P. Šimek, R. Zemek, G. Goldsworthy
- BiologyInsect Biochemistry and Molecular Biology
- 1 June 2000
Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants
- R. Vaclavikova, S. Horský, P. Šimek, I. Gut
- Biology, ChemistryNaunyn-Schmiedeberg's Archives of Pharmacology
- 14 August 2003
Oral administration of some phenolic substances might increase paclitaxel blood concentrations during chemotherapy by inhibiting metabolic inactivation in rat and human liver microsomes.
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