P. Šimek

Publications186
h-index35
Citations4,636
Highly Influential Citations142
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Long-Term Cold Acclimation Extends Survival Time at 0°C and Modifies the Metabolomic Profiles of the Larvae of the Fruit Fly Drosophila melanogaster
TLDR
It is found that long-term cold acclimation considerably improved cold tolerance in fully grown third-instar larvae of D. melanogaster and showed metabolic potential for the accumulation of proline and trehalose and for membrane restructuring. Expand
Hyperprolinemic larvae of the drosophilid fly, Chymomyza costata, survive cryopreservation in liquid nitrogen
TLDR
Increased the levels of proline in the larval tissues by feeding larvae proline-augmented diets and found that this simple treatment dramatically improved their freeze tolerance, providing direct evidence for the essential role of prolines in high freeze tolerance. Expand
Effects of acclimation temperature on thermal tolerance and membrane phospholipid composition in the fruit fly Drosophila melanogaster.
TLDR
Cold tolerance but not heat tolerance was influenced by preimaginal acclimation temperature and correlated with the changes in GPL composition in membranes of adult D. melanogaster. Expand
Cryoprotective role of polyols independent of the increase in supercooling capacity in diapausing adults of Pyrrhocoris apterus (Heteroptera: Insecta).
TLDR
Results were interpreted as evidence for the cryoprotective role of accumulated polyols independent of the depression of SCP, and Acclimation protocol using thermoperiod, mimicking daily temperature oscillations, resulted in moderately lower SCP, higher sum of polyols accumulated and significantly longer Lt50(-15) than at acclimation Protocol with constant temperatures. Expand
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
TLDR
The metabolism of docetaxel is the same in all four species, but metabolism of paclitaxe is different, and 6 alpha-OHP remains a uniquely human metabolite. Expand
Identification of xanthine and hypoxanthine as components of assembly pheromone in excreta of argasid ticks
In addition to guanine, xanthine and hypoxanthine were identified in white spherules in excreta of five species ofArgas andOrnithodoros ticks by a reverse-phase high-performance liquid chromatography… Expand
A new member of the AKH/RPCH family that stimulates locomotory activity in the firebug, Pyrrhocoris apterus (Heteroptera).
TLDR
A new member of the AKH/RPCH family was isolated and identified from the corpora cardiaca of the firebug Pyrrhocoris apterus, and is the first identified adipokinetic hormone described in a representative species of the suborder Heteroptera. Expand
Conversion of the chill susceptible fruit fly larva (Drosophila melanogaster) to a freeze tolerant organism
TLDR
It is shown that surprisingly simple laboratory manipulations can change the chill susceptible insect to the freeze tolerant one. Expand
Remodelling of membrane phospholipids during transition to diapause and cold-acclimation in the larvae of Chymomyza costata (Drosophilidae).
TLDR
The composition of molecular species of phosphatidylethanolamines and PCs was analysed in fat body and muscle tissues of Chymomyza costata larvae of different physiological states that markedly differed in their level of freeze-tolerance, and extensive remodelling of PL composition was found in these larvae in response to chilling. Expand
A novel R2R3 MYB transcription factor NtMYBJS1 is a methyl jasmonate-dependent regulator of phenylpropanoid-conjugate biosynthesis in tobacco.
TLDR
Results of both antisense expression analysis and of gel mobility shift assays strongly indicate that the NtMYBJS1 protein functions in tobacco MJ signal transduction, inducing phenylpropanoid biosynthetic genes and the accumulation of phenyl Propanoid-polyamine conjugates during stress. Expand
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