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Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert tumour-promoting functions, qualifying them as important therapeutic targets. Here, we show that the class I histone deacetylases HDAC1 and HDAC2(More)
Acknowledgements Thank you so much to my readers, Professor Tyler Moersch at Harvey Mudd College and Professor Anna Wenzel at Keck Science Department, for believing in me and this project. My deepest appreciation goes to Richard Moll, Chief Conservator at the Autry National Center, who provided me with the inspiration for this thesis, and who was(More)
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