P. W. Lehn

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A systematic approach to small-signal modelling of a micro-grid system that includes conventional (rotating machine) and electronically interfaced distributed resource (DR) units is presented here. The proposed approach incorporates fundamental frequency deviations in the overall system model and provides a methodology for the analysis of autonomous(More)
The species-specific pattern of cystic fibrosis transmembrane conductance regulator (CFTR) expression was investigated in order to identify species closely related to man which can be used as potential cystic fibrosis (CF) animal models. To this purpose, the nucleotide sequences of the CFTR promoter region of eight mammalian species representing four(More)
In absence of experimental 3D structures, several homology models, based on ABC exporter 3D structures, have provided significant insights into the molecular mechanisms underlying the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, a chloride channel whose defects are associated with cystic fibrosis (CF). Until now, these(More)
Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A major challenge for non-viral nanocarriers is the optimization of transgene expression in the targeted cells. This goal can be achieved(More)
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily that functions as an ATP-gated channel. Considerable progress has been made over the last years in the understanding of the molecular basis of the CFTR functions, as well as dysfunctions causing the common genetic(More)
—While a host of analysis techniques exist to perform steady-state analysis of open-loop converter systems, solutions for close-loop converter systems are distinctly more challenging to obtain. Analysis is done either via computationally intensive time-domain simulation or through reliance on a disconnected collection of published iteration techniques.(More)
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