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This paper presents an analysis of the FI4VDI project, the goal of which was to develop an innovative model of service provision using cloud computing in order to create an infrastructure suite aimed at large companies and SMEs alike, educational institutions, universities and/or research centers that would contribute to competitiveness and provide an(More)
Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the(More)
Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to(More)
Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity(More)
Integrated testing strategies (ITS), as opposed to single definitive tests or fixed batteries of tests, are expected to efficiently combine different information sources in a quantifiable fashion to satisfy an information need, in this case for regulatory safety assessments. With increasing awareness of the limitations of each individual tool and the(More)
SEURAT-1 is a joint research initiative between the European Commission and Cosmetics Europe aiming to develop in vitro- and in silico-based methods to replace the in vivo repeated dose systemic toxicity test used for the assessment of human safety. As one of the building blocks of SEURAT-1, the DETECTIVE project focused on a key element on which in vitro(More)
Standard Italian has a phonological rule that deletes word-final midvowels preceded by a sonorant in contexts where another word follows. This phenomenon is traditionally referred to as troncamento, and it is often considered an optional rule. Using a corpus of spoken Florentine Italian (Cresti & Moneglia, eds., 2005) and data from two informants, this(More)
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