P Thirupathi Reddy

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A novel and efficient reduction of various prochiral ketones such as acetopehones, alpha-azido aryl ketones, beta-ketoesters, and aliphatic acyclic and cyclic ketones to the corresponding optically acive secondary alcohols with moderate to excellent chemical yield was achieved by using Daucus carota, root plant cells under extremely mild and environmentally(More)
CPT-11, also known as irinotecan, is a prodrug that is approved for the treatment of advanced colorectal cancer. The active metabolite of CPT-11, SN38 (7-ethyl-10-hydroxy-camptothecin), has 100- to 1000-fold more potent cytotoxic activity in tissue cell culture compared with CPT-11. However, parental administration of SN38 is not possible because of its(More)
The oligonucleotide (oligo, ODN), Genasense (GS), an ODN currently waiting for FDA approval, was chosen as a model and modified with a 5' or 3' aminohexyl functionality (1 and 4, respectively) using solid-state synthesis. These amino derivatives were reacted with different releasable PEGs (rPEGs). The in vitro results of the PEG-modified oligos (Table 1)(More)
4.1. Aeruginosin 298-A 2002 4.2. Bleomycin 2003 4.3. Clavulones 2004 4.4. Curacin A 2005 4.5. Dysidiolide 2006 4.6. Epothilone 2006 4.7. Erythromycin A 2007 4.8. Estrone 2008 4.9. Fellutamide 2009 4.10. Fumiquinazoline 2010 4.11. Gougerotin 2010 4.12. Homocamptothecin 2010 4.13. Illudin 2011 4.14. Macrosphelide 2012 4.15. Mappicine 2012 4.16. Mniopetals and(More)
With the goal of identifying small molecule modulators of protein-protein interactions, we developed a solid-phase synthesis method, which was then successfully utilized in a library generation of 164 aminoindoline-derived, natural-product-like compounds. This library and several other related intermediates synthesized during this project were then(More)
A simple, selective, accurate reverse phase-high Performance Liquid Chromatographic (RP-HPLC) method was developed and validated for the analysis of Sildenafil Citrate in pharmaceutical formulations. Chromatographic separation achieved isocratically on a C18 column [Use Inertsil C18, 5μ , 150 mm x 4.6 mm] utilizing a mobile phase of acetonitrile/phosphate(More)
In order to overcome the problems of enzymatic degradation and short plasma half life, which can limit the delivery of antisense oligonucleotides, and the potential immuno-stimulatory effects of CpG motifs, we utilized a polyethylene glycol (PEG) technology that employed various releasable linkers (rPEG). 5'-20 kDa-PEGylation of an anti-Bcl-2(More)
A new amino PEG prodrug system, based entirely on aliphatic structures, has been designed using ester derivatives easily synthesized from N-modified bis-N-2-hydroxyethylglycinamides. Hydrolysis of the various promoiety bonds, in vivo, regenerated amine in a predictable manner. Thus, a novel new methodology for controlled release of amino-containing drugs,(More)
In this paper, we investigate the properties of neighbourhoods of functions for the classes U CV (α) and Sp(α). First we established an inclusion relationship between them and proved a necessary and sufficient condition interms of convolutions for a function f to be in Sp(α). Next we show that the class Sp(α) is closed under convolution with functions f (z)(More)