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In vitro and in vivo data have indicated that tumor cells actively internalize the low-density lipoprotein (LDL) from the circulation. A family of 2-(aminomethyl) acrylophenones (AMA) possesses an in vitro antileukemic activity but is devoid of any in vivo antineoplastic activity, because the compounds are actively captured by proteins in solution in the(More)
The effects of three polyols, mannitol, sorbitol and xylitol, on primary cultures of rat hepatocytes were studied with the aid of two cytotoxicity markers, the MTT test and the neutral red assay. A dose-related increase in the uptake of neutral red (up to approximately 60%) was observed in comparison with untreated cells, whereas the MTT test was unaffected(More)
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