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Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic(More)
Ninety seven eyes with anterior chamber implants and a best corrected visual acuity of at least 6/12 were studied, firstly, to compare the predictive accuracies of the commonly used formulas for intraocular lens (IOL) power calculation and, secondly, to determine the effect of optimising the 'A' constant on the predictive accuracies of the empirical(More)
Common genetic variants mapping to two distinct regions of RAD51B, a paralog of RAD51, have been associated with breast cancer risk in genome-wide association studies (GWAS). RAD51B is a plausible candidate gene because of its established role in the homologous recombination (HR) process. How germline genetic variation in RAD51B confers susceptibility to(More)
iii ACKNOWLEDGEMENTS I thank my esteemed Professors and mentors whom I have had the pleasure to learn from and interact with during my 2 years as a School of Public Health student. I eagerly look forward to utilizing the skills and life lessons I have obtained both in and outside of each of your classrooms. I thank Dr. Susan Sturgeon for her input as my(More)
During the creation of a new turbine blading a set of points are first obtained on the suction and pressure sides , by a fluid dynamics appr0ach.A smooth B-spline surface is made to pass through the points so obtained,and the surface manipulated interactively to achieve the desired smoothness and accuracy.To further check the blade surface and to obtain(More)
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