Learn More
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic(More)
Common genetic variants mapping to two distinct regions of RAD51B, a paralog of RAD51, have been associated with breast cancer risk in genome-wide association studies (GWAS). RAD51B is a plausible candidate gene because of its established role in the homologous recombination (HR) process. How germline genetic variation in RAD51B confers susceptibility to(More)
iii ACKNOWLEDGEMENTS I thank my esteemed Professors and mentors whom I have had the pleasure to learn from and interact with during my 2 years as a School of Public Health student. I eagerly look forward to utilizing the skills and life lessons I have obtained both in and outside of each of your classrooms. I thank Dr. Susan Sturgeon for her input as my(More)
During the creation of a new turbine blading a set of points are first obtained on the suction and pressure sides , by a fluid dynamics appr0ach.A smooth B-spline surface is made to pass through the points so obtained,and the surface manipulated interactively to achieve the desired smoothness and accuracy.To further check the blade surface and to obtain(More)
  • 1