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Over a quarter of drugs that enter clinical development fail because they are ineffective. Growing insight into genes that influence human disease may affect how drug targets and indications are selected. However, there is little guidance about how much weight should be given to genetic evidence in making these key decisions. To answer this question, we… (More)
MOTIVATION Expressed Sequence Tags (ESTs) are short single-pass DNA sequences obtained from either ends of cDNA clones. To exploit these sequences efficiently, a dynamic Web-tool has been developed which uses these data to perform fast virtual cloning of cDNAs. RESULTS Starting with a query sequence, the user is able to identify related ESTs and extend… (More)
SUMMARY A Java interface to radiation hybrid (RH) mapping software is described which enables users to build and interactively refine RH maps over the web. AVAILABILITY The Java applets described here are available on the internet at http://www.oxmol.com/biolib/webmap/.