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An understanding of the interactions between nanoparticles and biological systems is of significant interest. Studies aimed at correlating the properties of nanomaterials such as size, shape, chemical functionality, surface charge, and composition with biomolecular signaling, biological kinetics, transportation, and toxicity in both cell culture and animal(More)
Apoptosis has been considered as an underlying mechanism in acute lung injury/acute respiratory distress syndrome and multiorgan dysfunction syndrome. Recently, several alternative pathways for cell death (such as caspase-independent cell death, oncosis, and autophagy) have been discovered. Evidence of these pathways in the pathogenesis of acute lung injury(More)
Caspase-independent cell death has drawn increasing attention. In the present study, we found that lipopolysaccharide (LPS) accelerated spontaneous death of human lung epithelial A549 cells in a serum- and cell density-dependent manner: while serum starvation has been demonstrated to induce apoptosis in the same cell line, LPS-induced cell death was only(More)
OBJECTIVE To investigate the association of objectively measured hearing loss and depression in an older Chinese population. DESIGN Cross-sectional study. SETTING Screening service provided to the elderly as part of a charity program in collaboration with a local group of medical and audiologic professionals. METHODS A cross-sectional study was(More)
I The unicellular alga ChloreUa pyrenoidosa has been extensively studied with respect to its photosynthetic activities It exhibits a measurable rate of respiration in Knop solution without glucose; this respiration seems to differ from the more active respiration apparent when glucose is added to the medium (Emerson, 1926-27), as the two behave differently(More)
Engineered nanomaterials are used globally in biomedical, electronic, and optical devices, and are often discarded into the environment. Cell culture experiments have shown that many inorganic nanoparticles are toxic to eukaryotic cells. Here, we show that populations of eukaryotic cells can evolve to survive chronic exposure to toxic CdSe semiconductor(More)
Studying the effects of the physicochemical properties of nanomaterials on cellular uptake, toxicity, and exocytosis can provide the foundation for designing safer and more effective nanoparticles for clinical applications. However, an understanding of the effects of these properties on subcellular transport, accumulation, and distribution remains limited.(More)