P S Spilman

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STUDY OBJECTIVE To evaluate the effects of three chemically distinct nonsteroidal anti-inflammatory drugs (NSAIDs) on renal function in patients with asymptomatic, mild but stable chronic renal failure. DESIGN Prospectively randomized, triple-crossover study with at least 1-month washout between each of three treatment periods. SETTING Inpatient and(More)
The nonsteroidal antiinflammatory drugs are in wide use today. The use of these drugs, both over-the-counter and prescription strength, has risen dramatically for acute and chronic ailments. Of concern are patients with mild-to-moderate renal disease who may not recognize their increased risk of complications with the use of this category of drug.(More)
The purpose of this study was to evaluate the pharmacokinetics of sulindac, a purported "renal sparing" nonsteroidal anti-inflammatory drug, and its effects on renal function and prostaglandin excretion in patients with reduced glomerular filtration rate. Twelve female patients (glomerular filtration rate 37 +/- 4 mL/min) were treated with sulindac 200 mg(More)
Azlocillin is an important acylureido penicillin antibiotic for the management of complex gram-negative infections particularly those caused by Pseudomonas species. The current studies demonstrate that it manifests dose-dependent pharmacokinetics during the usual regimens of clinical dosing, that enterohepatic recirculation does not occur and that renal(More)
The maintenance of effective therapeutic concentrations of antibiotics within the renal parenchyma is an important issue in the management of acute and chronic pyelonephritis. Available clinical data indicate that an important clinical-therapeutic correlation exists between the physiologic state of the kidney and the antibiotic concentrations that can be(More)
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