P. S. Santos

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In the central nervous system (CNS), a number of different pathological processes such as necrosis, Parkinson’s and Alzheimer’s diseases are related to disturbance in calcium homeostasis associated with oxidative stress. Here we compare the susceptibility of rat brain plasma membrane Ca2+-ATPase (PMCA) and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA)(More)
Mobile agents are typically referred as a very adequate paradigm for using in mobile and disconnected computing environments. They are autonomous, have a strong sense of location and are able to operate independently of a central server. Nevertheless, although this is true, for developing a mobile agent system that is capable of operating in a disconnected(More)
Whole inactivated vaccines (WIVs) possess greater immunogenicity than split or subunit vaccines, and recent studies have demonstrated that WIVs with preserved fusogenic activity are more protective than non-fusogenic WIVs. In this work, we describe the inactivation of human influenza virus X-31 by high hydrostatic pressure (HHP) and analyze the effects on(More)
BACKGROUND Avian influenza A viruses can cross naturally into mammals and cause severe diseases, as observed for H5N1. The high lethality of human infections causes major concerns about the real risk of a possible pandemic of severe diseases to which human susceptibility may be high and universal. High hydrostatic pressure (HHP) is a valuable tool for(More)
In recent years, many applications in diverse scientific fields with various purposes have examined pressure as a thermodynamic parameter. Pressure studies on viruses have direct biotechnological applications. Currently, most studies that involve viral inactivation by HHP are found in the area of food engineering and focus on the inactivation of foodborne(More)
Fostering innovation and creativity is a priority in the science and education policy agenda of most countries, which have advocated that innovative minds and processes will boost scientific and economic growth. While our knowledge society has embraced this view, fostering creativity is among the major challenges faced by educators and policymakers. For(More)
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