P. Ram Kishore Kumar Reddy

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The objective of this study was to examine if RU486, a corticosteroid antagonist, modified hepatocyte metabolism and blocked the metabolic effects of exogenously administered cortisol in rainbow trout (Oncorhynchus mykiss). The fish were given a single intraperitoneal implant of either coconut oil alone or coconut oil containing RU486 (100 mg.kg-1),(More)
CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that(More)
In the present study, the effects of 17beta-estradiol (E(2)) treatment on the expression of preprosomatostatin (PPSS) I, PPSS II', and PPSS II" mRNA in the hypothalamus and endocrine pancreas (Brockmann body), as well as the effects of E(2) treatment on plasma somatostatin (SS)-14 and -25 concentrations in sexually immature rainbow trout (Oncorhynchus(More)
Incubation of fertilized eggs of Oreochromis mossambicus in media containing varying doses of T3, T4, and phenylthiocarbamide (PTC) indicated that the thyroid hormones delayed hatching, while the antithyroid drug accelerated it. Denuded eggs were also incubated in the above media and the media were assayed at various time intervals for hatching enzyme. The(More)
[125I]-Labelled iodomelatonin binding to brain membrane preparations was examined in adults of 4 species of salmonid fishes; 3 species were of cultured stock (Arctic charr, Atlantic salmon, rainbow trout) and 1 was taken from the wild (coho salmon). The specific binding of 2-[125I]iodomelatonin to the brain membrane preparations collected from all 4 species(More)
The enzymatic activities of alpha-amylase and its corresponding messenger RNA levels in developing sea bass (Lates calcarifer) larvae were studied from hatching until 27 days post hatching (dph). An increasing activity of amylase enzyme was measured until 5 dph, and the activity gradually decreased thereafter and reached a constant level by 12 dph. To(More)
This paper provides a technical aspects and design factors for selection of a right Brushless Direct Current (BLDC) motor for a CNC feed drive.To meet the most demanding requirements of CNC machine tools, robots and transfer lines in terms of productivity, accuracy and dynamic performance, brushless DC drives are very widely used. These drives employ(More)
1. Prostaglandin E1 (0.4 ml/kg, i.p.) significantly potentiated the antinociceptive action of morphine in albino rats. 2. This potentiation was significantly inhibited by pretreatment with reserpine, p-chlorophenylalanine or methysergide but not by alpha-methyl-p-tyrosine, phentolamine or propranolol. 3. The results suggest that the potentiation of morphine(More)
Prolactin is an important growth modulatory hormone in fetal and adult tissues. It stimulates DNA synthesis and enzymatic markers of the G1 phase of cell cycle in rat liver and other tissues. In this study the effects of prolactin on 5-methyl cytosine content in liver and kidney of rats was studied using HPLC. Prolactin treatment caused hypomethylation of(More)
The role of brain monoamines in the anticonvulsant effect of imipramine was investigated in albino rats, against maximal electroshock-induced seizures, by using drugs with well-defined effects on brain monoamines. The results suggest a definite role for noradrenaline in imipramine anticonvulsant action. Dopamine and 5-hydroxytryptamine do not appear to be(More)