P. Popov

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The experiments were carried out on Wistar rats, using a conflict situation consisting in opposition of two motivations: positive (water drinking) and negative (electrical pain). Two newly-synthesized piperazine derivatives with proved psychotropic activity (4P-183 and GP4) were studied and compared with the classical benzodiazepine tranquilizing agent(More)
In the review the authors describe the basic achievements in the given field: the discovery of receptors of opiates, localized on the cellular membrane of the neurone; investigation of their topographic distribution at various zones of the central nervous system: the discovery of endogenous ligands for opiate receptors-enkephalins and endorphins;(More)
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